The Protective Effect of Bergamot Oil Extract on Lecitine-like OxyLDL Receptor-1 Expression in Balloon Injury-related Neointima Formation
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- Vincenzo Mollace
- University “Magna Graecia" of Catanzaro, Italy, , San Raffaele Pisana IRCCS, Rome, Italy, Centro di Ricerca Salus, Bruzzano Zeffirio (Rc), Italy, Institute Mondino-Tor Vergata, Rome, Italy
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- Salvatore Ragusa
- University “Magna Graecia" of Catanzaro, Italy
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- Iolanda Sacco
- University “Magna Graecia" of Catanzaro, Italy
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- Carolina Muscoli
- University “Magna Graecia" of Catanzaro, Italy, San Raffaele Pisana IRCCS, Rome, Italy, Institute Mondino-Tor Vergata, Rome, Italy
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- Francesca Sculco
- University “Magna Graecia" of Catanzaro, Italy
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- Valeria Visalli
- University “Magna Graecia" of Catanzaro, Italy
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- Ernesto Palma
- University “Magna Graecia" of Catanzaro, Italy
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- Saverio Muscoli
- University of Rome “Tor Vergata", Rome, Italy
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- Luigi Mondello
- University of Messina, Italy
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- Paola Dugo
- University of Messina, Italy
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- Domenicantonio Rotiroti
- University “Magna Graecia" of Catanzaro, Italy
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- Francesco Romeo
- University of Rome “Tor Vergata", Rome, Italy
抄録
<jats:p> Lectin-like oxyLDL receptor-1 (LOX-1) has recently been suggested to be involved in smooth muscle cell (SMC) proliferation and neointima formation in injured blood vessels. This study evaluates the effect of the nonvolatile fraction (NVF), the antioxidant component of bergamot essential oil (BEO), on LOX-1 expression and free radical generation in a model of rat angioplasty. Common carotid arteries injured by balloon angioplasty were removed after 14 days for histopathological, biochemical, and immunohistochemical studies. Balloon injury led to a significant restenosis with SMC proliferation and neointima formation, accompanied by increased expression of LOX-1 receptor, malondialdehyde and superoxide formation, and nitrotyrosine staining. Pretreatment of rats with BEO-NVF reduced the neointima proliferation together with free radical formation and LOX-1 expression in a dose-dependent manner. These results suggest that natural antioxidants may be relevant in the treatment of vascular disorders in which proliferation of SMCs and oxyLDL-related endothelial cell dysfunction are involved. </jats:p>
収録刊行物
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- Journal of Cardiovascular Pharmacology and Therapeutics
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Journal of Cardiovascular Pharmacology and Therapeutics 13 (2), 120-129, 2008-06
SAGE Publications
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詳細情報 詳細情報について
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- CRID
- 1361418520763841408
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- ISSN
- 19404034
- 10742484
- http://id.crossref.org/issn/10742484
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- データソース種別
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- Crossref