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- Carlo Sala
- Consiglio Nazionale delle Ricerca Institute of Neuroscience and Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy; Neuromuscular Diseases and Neuroimmunology, Neurological Institute Foundation Carlo Besta, Milan, Italy; and Department of Neurobiology, The Weizmann Institute, Rehovot, Israel
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- Menahem Segal
- Consiglio Nazionale delle Ricerca Institute of Neuroscience and Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy; Neuromuscular Diseases and Neuroimmunology, Neurological Institute Foundation Carlo Besta, Milan, Italy; and Department of Neurobiology, The Weizmann Institute, Rehovot, Israel
書誌事項
- 公開日
- 2014-01
- DOI
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- 10.1152/physrev.00012.2013
- 公開者
- American Physiological Society
この論文をさがす
説明
<jats:p>The introduction of high-resolution time lapse imaging and molecular biological tools has changed dramatically the rate of progress towards the understanding of the complex structure-function relations in synapses of central spiny neurons. Standing issues, including the sequence of molecular and structural processes leading to formation, morphological change, and longevity of dendritic spines, as well as the functions of dendritic spines in neurological/psychiatric diseases are being addressed in a growing number of recent studies. There are still unsettled issues with respect to spine formation and plasticity: Are spines formed first, followed by synapse formation, or are synapses formed first, followed by emergence of a spine? What are the immediate and long-lasting changes in spine properties following exposure to plasticity-producing stimulation? Is spine volume/shape indicative of its function? These and other issues are addressed in this review, which highlights the complexity of molecular pathways involved in regulation of spine structure and function, and which contributes to the understanding of central synaptic interactions in health and disease.</jats:p>
収録刊行物
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- Physiological Reviews
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Physiological Reviews 94 (1), 141-188, 2014-01
American Physiological Society
