MAIT cell activation augments adenovirus vector vaccine immunogenicity
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- Nicholas M. Provine
- Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
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- Ali Amini
- Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
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- Lucy C. Garner
- Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
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- Alexandra J. Spencer
- Jenner Institute, University of Oxford, Oxford, UK.
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- Christina Dold
- Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, Oxford, UK.
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- Claire Hutchings
- Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK.
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- Laura Silva Reyes
- Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, Oxford, UK.
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- Michael E. B. FitzPatrick
- Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
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- Senthil Chinnakannan
- Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK.
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- Blanche Oguti
- Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, Oxford, UK.
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- Meriel Raymond
- Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, Oxford, UK.
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- Marta Ulaszewska
- Jenner Institute, University of Oxford, Oxford, UK.
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- Fulvia Troise
- Nouscom, SRL, Rome, Italy.
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- Hannah Sharpe
- Jenner Institute, University of Oxford, Oxford, UK.
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- Sophie B. Morgan
- Respiratory Medicine Unit, Nuffield Department of Medicine – Experimental Medicine, University of Oxford, Oxford, UK.
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- Timothy S. C. Hinks
- Respiratory Medicine Unit, Nuffield Department of Medicine – Experimental Medicine, University of Oxford, Oxford, UK.
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- Teresa Lambe
- Jenner Institute, University of Oxford, Oxford, UK.
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- Stefania Capone
- ReiThera, SRL, Rome, Italy.
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- Antonella Folgori
- ReiThera, SRL, Rome, Italy.
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- Eleanor Barnes
- Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
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- Christine S. Rollier
- Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, Oxford, UK.
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- Andrew J. Pollard
- Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, Oxford, UK.
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- Paul Klenerman
- Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
説明
<jats:title>Vaccines get a help-MAIT</jats:title> <jats:p> Mucosal-associated invariant T (MAIT) cells are a T cell subset important for mucosal homeostasis. These cells recognize derivatives of microbiota-derived vitamin B2 precursors but can also be activated by certain cytokines in the context of viral infections. Provine <jats:italic>et al.</jats:italic> report that a leading adenoviral vector vaccine, ChAdOx1, activated MAIT cells in immunized mice (see the Perspective by Juno and O'Connor). This activation required interferon-α produced by plasmacytoid dendritic cells as well as monocyte-derived interleukin-18 and tumor necrosis factor. MAIT cell activation positively correlated with vaccine-mediated T cell responses in human subjects, and mice deficient in MAIT cells showed impaired CD8 <jats:sup>+</jats:sup> T cell immunity to target antigens after vaccination. This work suggests an additional pathway that could be exploited to enhance the efficacy of vaccines. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6528" page="521" related-article-type="in-this-issue" vol="371" xlink:href="10.1126/science.aax8819">521</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6528" page="460" related-article-type="in-this-issue" vol="371" xlink:href="10.1126/science.abf8121">460</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 371 (6528), 521-526, 2021-01-29
American Association for the Advancement of Science (AAAS)
