Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening

Lewis R. Vidler, Panagis Filippakopoulos, Oleg Fedorov, Sarah Picaud, Sarah Martin, Michael Tomsett, Hannah Woodward, Nathan Brown, Stefan Knapp, Swen Hoelder

doi:10.1021/jm4011302

Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening

DOI Web Site 2 Citations

Lewis R. Vidler

Division of Cancer Therapeutics, Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, United Kingdom
Panagis Filippakopoulos

Nuffield Department of Clinical Medicine, Structural Genomics Consortium, Oxford University, Old Road Campus Research Building, Headington, Oxford OX3 7DQ, United Kingdom
Oleg Fedorov

Nuffield Department of Clinical Medicine, Structural Genomics Consortium, Oxford University, Old Road Campus Research Building, Headington, Oxford OX3 7DQ, United Kingdom
Sarah Picaud

Nuffield Department of Clinical Medicine, Structural Genomics Consortium, Oxford University, Old Road Campus Research Building, Headington, Oxford OX3 7DQ, United Kingdom
Sarah Martin

Nuffield Department of Clinical Medicine, Structural Genomics Consortium, Oxford University, Old Road Campus Research Building, Headington, Oxford OX3 7DQ, United Kingdom
Michael Tomsett

Division of Cancer Therapeutics, Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, United Kingdom
Hannah Woodward

Division of Cancer Therapeutics, Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, United Kingdom
Nathan Brown

Division of Cancer Therapeutics, Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, United Kingdom
Stefan Knapp

Nuffield Department of Clinical Medicine, Structural Genomics Consortium, Oxford University, Old Road Campus Research Building, Headington, Oxford OX3 7DQ, United Kingdom
Swen Hoelder

Division of Cancer Therapeutics, Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, United Kingdom

Journal

Journal of Medicinal Chemistry

Journal of Medicinal Chemistry 56 (20), 8073-8088, 2013-10-03

American Chemical Society (ACS)

Citations (2)*help

Details 詳細情報について

CRID

1361418521080009856
DOI

10.1021/jm4011302
ISSN

15204804

00222623
Web Site

https://pubs.acs.org/doi/pdf/10.1021/jm4011302
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