Advances in the Treatment of Acute Myeloid Leukemia: New Drugs and New Challenges

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  • Nicholas J. Short
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Marina Konopleva
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Tapan M. Kadia
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Gautam Borthakur
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Farhad Ravandi
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Courtney D. DiNardo
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Naval Daver
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Description

<jats:title>Abstract</jats:title><jats:sec><jats:title /><jats:p>The therapeutic armamentarium of acute myeloid leukemia (AML) has rapidly expanded in the past few years, driven largely by translational research into its genomic landscape and an improved understanding of mechanisms of resistance to conventional therapies. However, primary and secondary drug resistance remains a substantial problem for most patients. Research into the mechanisms of resistance to these new agents is informing the development of the next class of AML drugs and the design of combination regimens aimed at optimally exploiting therapeutic vulnerabilities, with the ultimate goal of eradicating all subclones of the disease and increasing cure rates in AML.</jats:p></jats:sec><jats:sec><jats:title>Significance:</jats:title><jats:p>AML is a heterogeneous disease, characterized by a broad spectrum of molecular alterations that influence clinical outcomes and also provide potential targets for drug development. This review discusses the current and emerging therapeutic landscape of AML, highlighting novel classes of drugs and how our expanding knowledge of mechanisms of resistance are informing future therapies and providing new opportunities for effective combination strategies.</jats:p></jats:sec>

Journal

  • Cancer Discovery

    Cancer Discovery 10 (4), 506-525, 2020-04-01

    American Association for Cancer Research (AACR)

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