VelB/VeA/LaeA Complex Coordinates Light Signal with Fungal Development and Secondary Metabolism

DOI Web Site 被引用文献15件
  • Özgür Bayram
    Institute of Microbiology and Genetics, Georg August University, D-37077 Göttingen, Germany.
  • Sven Krappmann
    Institute of Microbiology and Genetics, Georg August University, D-37077 Göttingen, Germany.
  • Min Ni
    Institute of Microbiology and Genetics, Georg August University, D-37077 Göttingen, Germany.
  • Jin Woo Bok
    Institute of Microbiology and Genetics, Georg August University, D-37077 Göttingen, Germany.
  • Kerstin Helmstaedt
    Institute of Microbiology and Genetics, Georg August University, D-37077 Göttingen, Germany.
  • Oliver Valerius
    Institute of Microbiology and Genetics, Georg August University, D-37077 Göttingen, Germany.
  • Susanna Braus-Stromeyer
    Institute of Microbiology and Genetics, Georg August University, D-37077 Göttingen, Germany.
  • Nak-Jung Kwon
    Institute of Microbiology and Genetics, Georg August University, D-37077 Göttingen, Germany.
  • Nancy P. Keller
    Institute of Microbiology and Genetics, Georg August University, D-37077 Göttingen, Germany.
  • Jae-Hyuk Yu
    Institute of Microbiology and Genetics, Georg August University, D-37077 Göttingen, Germany.
  • Gerhard H. Braus
    Institute of Microbiology and Genetics, Georg August University, D-37077 Göttingen, Germany.

抄録

<jats:p> Differentiation and secondary metabolism are correlated processes in fungi that respond to light. In <jats:italic>Aspergillus nidulans</jats:italic> , light inhibits sexual reproduction as well as secondary metabolism. We identified the heterotrimeric <jats:italic>velvet</jats:italic> complex VelB/VeA/LaeA connecting light-responding developmental regulation and control of secondary metabolism. VeA, which is primarily expressed in the dark, physically interacts with VelB, which is expressed during sexual development. VeA bridges VelB to the nuclear master regulator of secondary metabolism, LaeA. Deletion of either <jats:italic>velB</jats:italic> or <jats:italic>veA</jats:italic> results in defects in both sexual fruiting-body formation and the production of secondary metabolites. </jats:p>

収録刊行物

  • Science

    Science 320 (5882), 1504-1506, 2008-06-13

    American Association for the Advancement of Science (AAAS)

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