VelB/VeA/LaeA Complex Coordinates Light Signal with Fungal Development and Secondary Metabolism
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- Özgür Bayram
- Institute of Microbiology and Genetics, Georg August University, D-37077 Göttingen, Germany.
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- Sven Krappmann
- Institute of Microbiology and Genetics, Georg August University, D-37077 Göttingen, Germany.
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- Min Ni
- Institute of Microbiology and Genetics, Georg August University, D-37077 Göttingen, Germany.
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- Jin Woo Bok
- Institute of Microbiology and Genetics, Georg August University, D-37077 Göttingen, Germany.
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- Kerstin Helmstaedt
- Institute of Microbiology and Genetics, Georg August University, D-37077 Göttingen, Germany.
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- Oliver Valerius
- Institute of Microbiology and Genetics, Georg August University, D-37077 Göttingen, Germany.
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- Susanna Braus-Stromeyer
- Institute of Microbiology and Genetics, Georg August University, D-37077 Göttingen, Germany.
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- Nak-Jung Kwon
- Institute of Microbiology and Genetics, Georg August University, D-37077 Göttingen, Germany.
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- Nancy P. Keller
- Institute of Microbiology and Genetics, Georg August University, D-37077 Göttingen, Germany.
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- Jae-Hyuk Yu
- Institute of Microbiology and Genetics, Georg August University, D-37077 Göttingen, Germany.
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- Gerhard H. Braus
- Institute of Microbiology and Genetics, Georg August University, D-37077 Göttingen, Germany.
説明
<jats:p> Differentiation and secondary metabolism are correlated processes in fungi that respond to light. In <jats:italic>Aspergillus nidulans</jats:italic> , light inhibits sexual reproduction as well as secondary metabolism. We identified the heterotrimeric <jats:italic>velvet</jats:italic> complex VelB/VeA/LaeA connecting light-responding developmental regulation and control of secondary metabolism. VeA, which is primarily expressed in the dark, physically interacts with VelB, which is expressed during sexual development. VeA bridges VelB to the nuclear master regulator of secondary metabolism, LaeA. Deletion of either <jats:italic>velB</jats:italic> or <jats:italic>veA</jats:italic> results in defects in both sexual fruiting-body formation and the production of secondary metabolites. </jats:p>
収録刊行物
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- Science
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Science 320 (5882), 1504-1506, 2008-06-13
American Association for the Advancement of Science (AAAS)