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- Alborz Mahdavi
- *Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139-4307;
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- Lino Ferreira
- *Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139-4307;
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- Cathryn Sundback
- Center for Regenerative Medicine and
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- Jason W. Nichol
- Harvard–Massachusetts Institute of Technology, Division of Health Science and Technology, Cambridge, MA 02139;
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- Edwin P. Chan
- Harvard–Massachusetts Institute of Technology, Division of Health Science and Technology, Cambridge, MA 02139;
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- David J. D. Carter
- The Charles Stark Draper Laboratory, Cambridge, MA 02139-3563;
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- Chris J. Bettinger
- Harvard–Massachusetts Institute of Technology, Division of Health Science and Technology, Cambridge, MA 02139;
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- Siamrut Patanavanich
- *Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139-4307;
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- Loice Chignozha
- *Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139-4307;
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- Eli Ben-Joseph
- *Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139-4307;
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- Alex Galakatos
- *Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139-4307;
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- Howard Pryor
- Center for Regenerative Medicine and
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- Irina Pomerantseva
- Center for Regenerative Medicine and
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- Peter T. Masiakos
- Departments of **Pediatric Surgery and
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- William Faquin
- Pathology, Massachusetts General Hospital, Boston, MA 02114;
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- Andreas Zumbuehl
- Biozentrum, University of Basel, Klingelbergstrasse 50/70, 4056 Basel, Switzerland; and
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- Seungpyo Hong
- *Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139-4307;
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- Jeffrey Borenstein
- The Charles Stark Draper Laboratory, Cambridge, MA 02139-3563;
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- Joseph Vacanti
- Center for Regenerative Medicine and
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- Robert Langer
- *Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139-4307;
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- Jeffrey M. Karp
- Harvard Medical School, Boston, MA 02115;
説明
<jats:p> There is a significant medical need for tough biodegradable polymer adhesives that can adapt to or recover from various mechanical deformations while remaining strongly attached to the underlying tissue. We approached this problem by using a polymer poly(glycerol-co-sebacate acrylate) and modifying the surface to mimic the nanotopography of gecko feet, which allows attachment to vertical surfaces. Translation of existing gecko-inspired adhesives for medical applications is complex, as multiple parameters must be optimized, including: biocompatibility, biodegradation, strong adhesive tissue bonding, as well as compliance and conformability to tissue surfaces. Ideally these adhesives would also have the ability to deliver drugs or growth factors to promote healing. As a first demonstration, we have created a gecko-inspired tissue adhesive from a biocompatible and biodegradable elastomer combined with a thin tissue-reactive biocompatible surface coating. Tissue adhesion was optimized by varying dimensions of the nanoscale pillars, including the ratio of tip diameter to pitch and the ratio of tip diameter to base diameter. Coating these nanomolded pillars of biodegradable elastomers with a thin layer of oxidized dextran significantly increased the interfacial adhesion strength on porcine intestine tissue <jats:italic>in vitro</jats:italic> and in the rat abdominal subfascial <jats:italic>in vivo</jats:italic> environment. This gecko-inspired medical adhesive may have potential applications for sealing wounds and for replacement or augmentation of sutures or staples. </jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 105 (7), 2307-2312, 2008-02-19
Proceedings of the National Academy of Sciences