C-Reactive Protein and the 10-Year Incidence of Coronary Heart Disease in Older Men and Women
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- Mary Cushman
- From the Departments of Medicine and Pathology (M.C.) and Pathology and Biochemistry (R.P.T.), University of Vermont, Burlington; Departments of Biostatistics (A.M.A.) and Medicine, Epidemiology, and Health Services (B.M.P.), University of Washington, Seattle; Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Md (T.A.M.); Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pa (L.H.K.); Department of Public Health Sciences, Wake...
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- Alice M. Arnold
- From the Departments of Medicine and Pathology (M.C.) and Pathology and Biochemistry (R.P.T.), University of Vermont, Burlington; Departments of Biostatistics (A.M.A.) and Medicine, Epidemiology, and Health Services (B.M.P.), University of Washington, Seattle; Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Md (T.A.M.); Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pa (L.H.K.); Department of Public Health Sciences, Wake...
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- Bruce M. Psaty
- From the Departments of Medicine and Pathology (M.C.) and Pathology and Biochemistry (R.P.T.), University of Vermont, Burlington; Departments of Biostatistics (A.M.A.) and Medicine, Epidemiology, and Health Services (B.M.P.), University of Washington, Seattle; Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Md (T.A.M.); Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pa (L.H.K.); Department of Public Health Sciences, Wake...
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- Teri A. Manolio
- From the Departments of Medicine and Pathology (M.C.) and Pathology and Biochemistry (R.P.T.), University of Vermont, Burlington; Departments of Biostatistics (A.M.A.) and Medicine, Epidemiology, and Health Services (B.M.P.), University of Washington, Seattle; Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Md (T.A.M.); Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pa (L.H.K.); Department of Public Health Sciences, Wake...
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- Lewis H. Kuller
- From the Departments of Medicine and Pathology (M.C.) and Pathology and Biochemistry (R.P.T.), University of Vermont, Burlington; Departments of Biostatistics (A.M.A.) and Medicine, Epidemiology, and Health Services (B.M.P.), University of Washington, Seattle; Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Md (T.A.M.); Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pa (L.H.K.); Department of Public Health Sciences, Wake...
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- Gregory L. Burke
- From the Departments of Medicine and Pathology (M.C.) and Pathology and Biochemistry (R.P.T.), University of Vermont, Burlington; Departments of Biostatistics (A.M.A.) and Medicine, Epidemiology, and Health Services (B.M.P.), University of Washington, Seattle; Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Md (T.A.M.); Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pa (L.H.K.); Department of Public Health Sciences, Wake...
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- Joseph F. Polak
- From the Departments of Medicine and Pathology (M.C.) and Pathology and Biochemistry (R.P.T.), University of Vermont, Burlington; Departments of Biostatistics (A.M.A.) and Medicine, Epidemiology, and Health Services (B.M.P.), University of Washington, Seattle; Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Md (T.A.M.); Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pa (L.H.K.); Department of Public Health Sciences, Wake...
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- Russell P. Tracy
- From the Departments of Medicine and Pathology (M.C.) and Pathology and Biochemistry (R.P.T.), University of Vermont, Burlington; Departments of Biostatistics (A.M.A.) and Medicine, Epidemiology, and Health Services (B.M.P.), University of Washington, Seattle; Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Md (T.A.M.); Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pa (L.H.K.); Department of Public Health Sciences, Wake...
Bibliographic Information
- Other Title
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- The Cardiovascular Health Study
Description
<jats:p> <jats:bold> <jats:italic>Background—</jats:italic> </jats:bold> High C-reactive protein (CRP) is associated with increased coronary heart disease risk. Few long-term data in the elderly are available. </jats:p> <jats:p> <jats:bold> <jats:italic>Methods and Results—</jats:italic> </jats:bold> Baseline CRP was measured in 3971 men and women ≥65 years of age without prior vascular diseases; 26% had elevated concentrations (>3 mg/L). With 10 years of follow-up, 547 participants developed coronary heart disease (CHD; defined as myocardial infarction or coronary death). With elevated CRP, the 10-year cumulative CHD incidences were 33% in men and 17% in women. The age-, ethnicity-, and sex-adjusted relative risk of CHD for CRP >3 mg/L compared with <1 mg/L was 1.82 (95% CI, 1.46 to 2.28). Adjusting for conventional risk factors reduced the relative risk to 1.45 (95% CI, 1.14 to 1.86). The population-attributable risk of CHD for elevated CRP was 11%. Risk relationships did not differ in subgroups defined by baseline risk factors. We assessed whether CRP improved prediction by the Framingham Risk Score. Among men with a 10-year Framingham-predicted risk of 10% to 20%, the observed CHD incidence was 32% for elevated CRP. Among women, CRP discriminated best among those with a 10-year predicted risk >20%; the incidences were 31% and 10% for elevated and normal CRP levels, respectively. </jats:p> <jats:p> <jats:bold> <jats:italic>Conclusions—</jats:italic> </jats:bold> In older men and women, elevated CRP was associated with increased 10-year risk of CHD, regardless of the presence or absence of cardiac risk factors. A single CRP measurement provided information beyond conventional risk assessment, especially in intermediate-Framingham-risk men and high-Framingham-risk women. </jats:p>
Journal
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- Circulation
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Circulation 112 (1), 25-31, 2005-07-05
Ovid Technologies (Wolters Kluwer Health)
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Details 詳細情報について
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- CRID
- 1361418521407763840
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- NII Article ID
- 30022672938
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- ISSN
- 15244539
- 00097322
- http://id.crossref.org/issn/00097322
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- Data Source
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- Crossref
- CiNii Articles