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- Martin C. Moore-Ede
- Department of Physiology and Biophysics, Harvard Medical School, Boston, Massachusetts 02115
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- Gary S. Richardson
- Department of Physiology and Biophysics, Harvard Medical School, Boston, Massachusetts 02115
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説明
<jats:p> The circadian pacemakers, which time the approximately 24-hour rhythms in sleep and wakefulness, neuroendocrine, thermoregulatory, and other body functions, resynchronize only slowly after an abrupt phase shift in environmental time cues. While the symptoms of jet-lag are transient, the kinds of repeated shifts over a number of years experienced by shift-workers on rotating schedules induce sleep-wake disorders, gastrointestinal pathology, and an increased risk of cardiovascular disease. There is significant interindividual variation in the ability to adapt and also a deterioration with age. Evidence is accumulating that poor adapters present with a Shift Maladaption Syndrome with characteristic pathological manifestations. </jats:p>
収録刊行物
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- Annual Review of Medicine
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Annual Review of Medicine 36 (1), 607-617, 1985-02
Annual Reviews