Plasma Exchange Is Highly Effective for Anti‐Neutrophil Cytoplasmic Antibody‐Associated Vasculitis Patients With Rapidly Progressive Glomerulonephritis Who Have Advanced to Dialysis Dependence: A Single‐Center Case Series
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- Reimi Nishida
- Department of Nephrology and Pathology, Faculty of Medicine University of Tsukuba Ibaraki Japan
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- Shuzo Kaneko
- Department of Nephrology and Pathology, Faculty of Medicine University of Tsukuba Ibaraki Japan
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- Joichi Usui
- Department of Nephrology and Pathology, Faculty of Medicine University of Tsukuba Ibaraki Japan
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- Tetsuya Kawamura
- Department of Nephrology and Pathology, Faculty of Medicine University of Tsukuba Ibaraki Japan
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- Ryoya Tsunoda
- Department of Nephrology and Pathology, Faculty of Medicine University of Tsukuba Ibaraki Japan
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- Takashi Tawara
- Department of Nephrology and Pathology, Faculty of Medicine University of Tsukuba Ibaraki Japan
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- Akiko Fujita
- Department of Nephrology and Pathology, Faculty of Medicine University of Tsukuba Ibaraki Japan
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- Kei Nagai
- Department of Nephrology and Pathology, Faculty of Medicine University of Tsukuba Ibaraki Japan
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- Hirayasu Kai
- Department of Nephrology and Pathology, Faculty of Medicine University of Tsukuba Ibaraki Japan
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- Naoki Morito
- Department of Nephrology and Pathology, Faculty of Medicine University of Tsukuba Ibaraki Japan
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- Chie Saito
- Department of Nephrology and Pathology, Faculty of Medicine University of Tsukuba Ibaraki Japan
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- Kunihiro Yamagata
- Department of Nephrology and Pathology, Faculty of Medicine University of Tsukuba Ibaraki Japan
書誌事項
- 公開日
- 2019-06
- 資源種別
- journal article
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1111/1744-9987.12830
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p>Plasma exchange (PEX) can be an effective treatment in anti‐neutrophil cytoplasmic antibody‐associated vasculitis with severe renal damage; however, it is still controversial. Among cases of newly diagnosed AAV with rapidly progressive glomerulonephritis at our department from 2008 onward, 11 patients who received PEX (seven cases for severe renal damage [R‐PEX] and four cases for lung hemorrhage [L‐PEX]) were retrospectively analyzed. All cases of R‐PEX were dependent on hemodialysis at the beginning of PEX and all received seven sessions of PEX (50 mL/kg or 1.3 plasma volume per exchange) within 2 weeks. All cases became dialysis‐independent within 8 weeks, with 3‐ and 12‐month cumulative renal survival rates of 100% and 80%, respectively. All cases of L‐PEX retained their renal function. In rapidly developing, newly dialysis‐dependent antibody‐associated vasculitis with rapidly progressive glomerulonephritis patients with normal renal function before disease onset, standard PEX can be expected to induce sufficient renal recovery to establish dialysis independence.</jats:p>
収録刊行物
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- Therapeutic Apheresis and Dialysis
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Therapeutic Apheresis and Dialysis 23 (3), 253-260, 2019-06
Wiley