Role of neuron and non-neuronal cell communication in persistent orofacial pain
-
- Koichi Iwata
- Department of Physiology, Nihon University School of Dentistry, Tokyo, Japan.
-
- Masamichi Shinoda
- Department of Physiology, Nihon University School of Dentistry, Tokyo, Japan.
書誌事項
- 公開日
- 2019
- 資源種別
- journal article
- 権利情報
-
- http://creativecommons.org/licenses/by-nc/4.0/
- DOI
-
- 10.17245/jdapm.2019.19.2.77
- 公開者
- XMLink
この論文をさがす
説明
It is well known that trigeminal nerve injury causes hyperexcitability in trigeminal ganglion neurons, which become sensitized. Long after trigeminal nerve damage, trigeminal spinal subnucleus caudalis and upper cervical spinal cord (C1/C2) nociceptive neurons become hyperactive and are sensitized, resulting in persistent orofacial pain. Communication between neurons and non-neuronal cells is believed to be involved in these mechanisms. In this article, the authors highlight several lines of evidence that neuron-glial cell and neuron macrophage communication have essential roles in persistent orofacial pain mechanisms associated with trigeminal nerve injury and/or orofacial inflammation.
収録刊行物
-
- Journal of Dental Anesthesia and Pain Medicine
-
Journal of Dental Anesthesia and Pain Medicine 19 (2), 77-, 2019
XMLink
