-
- Anders H. Rosengren
- Lund University Diabetes Centre, Malmö, SE-20502 Malmö, Sweden.
-
- Ramunas Jokubka
- Lund University Diabetes Centre, Malmö, SE-20502 Malmö, Sweden.
-
- Damon Tojjar
- Lund University Diabetes Centre, Malmö, SE-20502 Malmö, Sweden.
-
- Charlotte Granhall
- Lund University Diabetes Centre, Malmö, SE-20502 Malmö, Sweden.
-
- Ola Hansson
- Lund University Diabetes Centre, Malmö, SE-20502 Malmö, Sweden.
-
- Dai-Qing Li
- Key Laboratory of Hormones and Development, Ministry of Health, China, Tianjin Metabolic Diseases Hospital, Tianjin Medical University, China.
-
- Vini Nagaraj
- Lund University Diabetes Centre, Malmö, SE-20502 Malmö, Sweden.
-
- Thomas M. Reinbothe
- Lund University Diabetes Centre, Malmö, SE-20502 Malmö, Sweden.
-
- Jonatan Tuncel
- Section for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden.
-
- Lena Eliasson
- Lund University Diabetes Centre, Malmö, SE-20502 Malmö, Sweden.
-
- Leif Groop
- Lund University Diabetes Centre, Malmö, SE-20502 Malmö, Sweden.
-
- Patrik Rorsman
- Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK.
-
- Albert Salehi
- Lund University Diabetes Centre, Malmö, SE-20502 Malmö, Sweden.
-
- Valeriya Lyssenko
- Lund University Diabetes Centre, Malmö, SE-20502 Malmö, Sweden.
-
- Holger Luthman
- Lund University Diabetes Centre, Malmö, SE-20502 Malmö, Sweden.
-
- Erik Renström
- Lund University Diabetes Centre, Malmö, SE-20502 Malmö, Sweden.
書誌事項
- 公開日
- 2010-01-08
- DOI
-
- 10.1126/science.1176827
- 公開者
- American Association for the Advancement of Science (AAAS)
この論文をさがす
説明
<jats:title>Ratting Out a Diabetes Gene</jats:title> <jats:p> Inbred animals with inherited susceptibility to disease can be especially informative regarding pathogenetic mechanisms because they carry naturally occurring genetic variants of the same type that cause disease in humans. This principle is illustrated by <jats:bold> Rosengren <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="217" related-article-type="in-this-issue" vol="327" xlink:href="10.1126/science.1176827">217</jats:related-article> ; published online 19 November), whose analysis of an inbred strain of rats prone to develop type 2 diabetes led to the discovery of a gene whose aberrant overexpression suppresses pancreatic insulin secretion in both rats and humans. The culprit gene, ADRA2A, encodes the alpha2A adrenergic receptor and is potentially a valuable lead for diabetes therapy because it can be targeted pharmacologically. </jats:p>
収録刊行物
-
- Science
-
Science 327 (5962), 217-220, 2010-01-08
American Association for the Advancement of Science (AAAS)