Curtailed, a new dominant T-allele in the house mouse

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<jats:p>Curtailed (<jats:italic>T<jats:sup>c</jats:sup></jats:italic>) is a new T-allele which leads to complete or near-complete absence of the tail in heterozygotes, apart from a small caudal filament. Other heterozygous defects include absence of the axis odontoid process and of the nuclei pulposi, a tendency to have rib and vertebral fusions and a slight decrease in the average number of presacral vertebrae. <jats:italic>T<jats:sup>c</jats:sup></jats:italic> is lethal when homozygous, causing similar but more extreme defects than <jats:italic>T</jats:italic>, with absence of all limb-buds and non-closure of the neural folds. A comparison of <jats:italic>T<jats:sup>c</jats:sup></jats:italic> with other mutants suggests that the anomalies are mainly the result of more severe effects on the notochord-mesoderm system than in <jats:italic>T</jats:italic>. Differences between the genetic behaviour of <jats:italic>T</jats:italic>, <jats:italic>T<jats:sup>c</jats:sup></jats:italic> and <jats:italic>T<jats:sup>h</jats:sup></jats:italic> are discussed.</jats:p>

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