Androstenetriol and Androstenediol: Protection Against Lethal Radiation and Restoration of Immunity After Radiation Injury

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書誌事項

公開日
2000-01
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1111/j.1749-6632.2000.tb05452.x
公開者
Wiley

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<jats:p><jats:bold>A<jats:sc>bstract</jats:sc>: </jats:bold> Androstenetriol (AET) and Androstenediol (AED) upregulate host immunity, leading to increased resistance against infections. AET augments IL‐2, IL‐3, IFNγ levels, and counteracts hydrocortisone immune suppression. AET and AED at a dose of 0.75 mg/‐ and 8.0 mg/25‐g mouse, protected 60 and 70%, respectively, of C57/BL/6J mice irradiated with a lethal dose. These hormones also protected mice irradiated with 6 Gy and infected with a coxsackievirus B4 LD50. AET significantly increased spleen lymphocyte numbers at 7, 14, and 21 days after a 6‐Gy exposure. Fluorescent activated cell‐sorter analysis of irradiated mice, spleen, and bone marrow showed that AET significantly augmented the myeloid precursor markers, CD11b/Mac‐1, and B220 (pan B), as well as the absolute numbers of CD4+/CD8+ cells over the 21 days of testing. Overall, the data are consistent with AET/AED inducing a more rapid recovery of all hematopoietic precursors from the small number of surviving stem cells.</jats:p>

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