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- Marc Ringehan
- Institute of Virology, Technical University of Munich/Helmholtz Zentrum München, Trogerstrasse 30, 81675 Muenchen, Germany
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- Jane A. McKeating
- Institute for Advanced Science, Technical University of Munich, Muenchen, Germany
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- Ulrike Protzer
- Institute of Virology, Technical University of Munich/Helmholtz Zentrum München, Trogerstrasse 30, 81675 Muenchen, Germany
説明
<jats:p>Hepatitis B and C viruses are a global health problem causing acute and chronic infections that can lead to liver cirrhosis and hepatocellular carcinoma (HCC). These infections are the leading cause for HCC worldwide and are associated with significant mortality, accounting for more than 1.3 million deaths per year. Owing to its high incidence and resistance to treatment, liver cancer is the second leading cause of cancer-related death worldwide, with HCC representing approximately 90% of all primary liver cancer cases. The majority of viral-associated HCC cases develop in subjects with liver cirrhosis; however, hepatitis B virus infection can promote HCC development without prior end-stage liver disease. Thus, understanding the role of hepatitis B and C viral infections in HCC development is essential for the future design of treatments and therapies for this cancer. In this review, we summarize the current knowledge on hepatitis B and C virus hepatocarcinogenesis and highlight direct and indirect risk factors.</jats:p> <jats:p>This article is part of the themed issue ‘Human oncogenic viruses’.</jats:p>
収録刊行物
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- Philosophical Transactions of the Royal Society B: Biological Sciences
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Philosophical Transactions of the Royal Society B: Biological Sciences 372 (1732), 20160274-, 2017-09-11
The Royal Society
