β-Catenin directly regulates <i>Islet1</i> expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis
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- Lizhu Lin
- *Skaggs School of Pharmacy and Pharmaceutical Sciences,
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- Li Cui
- *Skaggs School of Pharmacy and Pharmaceutical Sciences,
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- Wenlai Zhou
- Howard Hughes Medical Institute and Department of Medicine, and
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- Daniel Dufort
- Department of Obstetrics and Gynecology, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, QC, Canada H3A 1A1; and
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- Xiaoxue Zhang
- *Skaggs School of Pharmacy and Pharmaceutical Sciences,
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- Chen-Leng Cai
- *Skaggs School of Pharmacy and Pharmaceutical Sciences,
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- Lei Bu
- *Skaggs School of Pharmacy and Pharmaceutical Sciences,
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- Lei Yang
- *Skaggs School of Pharmacy and Pharmaceutical Sciences,
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- Jody Martin
- *Skaggs School of Pharmacy and Pharmaceutical Sciences,
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- Rolf Kemler
- Max-Planck-Institute of Immunobiology, Stubeweg 51, 79108 Freiburg, Germany
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- Michael G. Rosenfeld
- Howard Hughes Medical Institute and Department of Medicine, and
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- Ju Chen
- School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093;
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- Sylvia M. Evans
- *Skaggs School of Pharmacy and Pharmaceutical Sciences,
書誌事項
- 公開日
- 2007-05-29
- DOI
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- 10.1073/pnas.0700923104
- 公開者
- Proceedings of the National Academy of Sciences
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説明
<jats:p> Recent studies have demonstrated that the LIM homeodomain transcription factor Islet1 (Isl1) marks pluripotent cardiovascular progenitor cells and is required for proliferation, survival, and migration of recently defined second heart field progenitors. Factors that are upstream of <jats:italic>Isl1</jats:italic> in cardiovascular progenitors have not yet been defined. Here we demonstrate that β-catenin is required for <jats:italic>Isl1</jats:italic> expression in cardiac progenitors, directly regulating the <jats:italic>Isl1</jats:italic> promoter. Ablation of β- <jats:italic>catenin</jats:italic> in Isl1-expressing progenitors disrupts multiple aspects of cardiogenesis, resulting in embryonic lethality at E13. β-Catenin is also required upstream of a number of genes required for pharyngeal arch, outflow tract, and/or atrial septal morphogenesis, including <jats:italic>Tbx2</jats:italic> , <jats:italic>Tbx3</jats:italic> , <jats:italic>Wnt11</jats:italic> , <jats:italic>Shh</jats:italic> , and <jats:italic>Pitx2</jats:italic> . Our findings demonstrate that β-catenin signaling regulates proliferation and survival of cardiac progenitors. </jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 104 (22), 9313-9318, 2007-05-29
Proceedings of the National Academy of Sciences