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Dodeca-CLE Peptides as Suppressors of Plant Stem Cell Differentiation
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- Yasuko Ito
- Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
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- Ikuko Nakanomyo
- Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
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- Hiroyasu Motose
- Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
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- Kuninori Iwamoto
- Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
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- Shinichiro Sawa
- Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
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- Naoshi Dohmae
- Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
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- Hiroo Fukuda
- Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
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Description
<jats:p> In plants and animals, small peptide ligands that signal in cell-cell communication have been suggested to be a crucial component of development. A bioassay of single-cell transdifferentation demonstrates that a dodecapeptide with two hydroxyproline residues is the functional product of genes from the <jats:italic>CLE</jats:italic> family, which includes <jats:italic>CLAVATA3</jats:italic> in <jats:italic>Arabidopsis</jats:italic> . The dodecapeptide suppresses xylem cell development at a concentration of 10 <jats:sup>–11</jats:sup> M and promotes cell division. An application, corresponding to all 26 <jats:italic>Arabidopsis</jats:italic> CLE protein family members, of synthetic dodecapeptides reveals two counteracting signaling pathways involved in stem cell fate. </jats:p>
Journal
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- Science
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Science 313 (5788), 842-845, 2006-08-11
American Association for the Advancement of Science (AAAS)