Aggregate penetrance of genomic variants for actionable disorders in European and African Americans
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- Pradeep Natarajan
- Center for Human Genetic Research, Cardiovascular Research Center, and Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
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- Nina B. Gold
- Harvard Medical School, Boston, MA 02115, USA.
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- Alexander G. Bick
- Harvard Medical School, Boston, MA 02115, USA.
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- Heather McLaughlin
- Harvard Medical School, Boston, MA 02115, USA.
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- Peter Kraft
- Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
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- Heidi L. Rehm
- Harvard Medical School, Boston, MA 02115, USA.
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- Gina M. Peloso
- Harvard Medical School, Boston, MA 02115, USA.
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- James G. Wilson
- Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA.
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- Adolfo Correa
- Departments of Pediatrics and Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.
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- Jonathan G. Seidman
- Harvard Medical School, Boston, MA 02115, USA.
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- Christine E. Seidman
- Harvard Medical School, Boston, MA 02115, USA.
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- Sekar Kathiresan
- Center for Human Genetic Research, Cardiovascular Research Center, and Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
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- Robert C. Green
- Harvard Medical School, Boston, MA 02115, USA.
書誌事項
- 公開日
- 2016-11-09
- 権利情報
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- http://www.sciencemag.org/about/science-licenses-journal-article-reuse
- DOI
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- 10.1126/scitranslmed.aag2367
- 公開者
- American Association for the Advancement of Science (AAAS)
この論文をさがす
説明
<jats:p>In two separate analyses, people with disease-associated mutations exhibited features of the corresponding disease more often than expected, a result that supports the use of population-based genetic screening.</jats:p>
収録刊行物
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- Science Translational Medicine
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Science Translational Medicine 8 (364), 2016-11-09
American Association for the Advancement of Science (AAAS)