Adiponectin Concentration in Umbilical Cord Serum Is Positively Associated with the Weight Ratio of Fetus to Placenta

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  • Kozo Kadowaki
    Departments of Obstetrics (K.K., N.S.), Osaka 594-1101, Japan
  • Masako Waguri
    Internal Medicine (M.W., I.N., Y.M., T.Fuj.), Osaka 594-1101, Japan
  • Isao Nakanishi
    Internal Medicine (M.W., I.N., Y.M., T.Fuj.), Osaka 594-1101, Japan
  • Yoshihiro Miyashita
    Internal Medicine (M.W., I.N., Y.M., T.Fuj.), Osaka 594-1101, Japan
  • Masahiro Nakayama
    Pathology (M.N.), Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Osaka 594-1101, Japan
  • Noriyuki Suehara
    Departments of Obstetrics (K.K., N.S.), Osaka 594-1101, Japan
  • Tohru Funahashi
    Department of Internal Medicine and Molecular Science (T.Fun., I.S.), Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
  • Iichiro Shimomura
    Department of Internal Medicine and Molecular Science (T.Fun., I.S.), Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
  • Tomio Fujita
    Internal Medicine (M.W., I.N., Y.M., T.Fuj.), Osaka 594-1101, Japan

書誌事項

公開日
2006-12-01
DOI
  • 10.1210/jc.2005-2846
公開者
The Endocrine Society

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<jats:title>Abstract</jats:title> <jats:p>Context: Adiponectin (APN) concentration in umbilical cord serum is higher than that in adult serum. Except for the positive association between birth weight and cord APN concentration, little is known about the pathophysiological function of APN in fetal development.</jats:p> <jats:p>Objective: The objective of this study was to evaluate the relationship of cord serum APN and IGF-I concentrations with the development of the fetoplacental unit.</jats:p> <jats:p>Design and Methods: Umbilical cord serum APN and IGF-I concentrations were measured in term singleton deliveries (n = 94). The association of cord APN and IGF-I concentrations was evaluated in relation to fetal weight, placental weight, and fetoplacental (F/P) weight ratio.</jats:p> <jats:p>Results: Mean concentrations and sd of APN and IGF-I were 36.1 ± 14.0 μg/ml and 58.6 ± 27.0 ng/ml, respectively. Cord APN concentration was positively associated with F/P weight ratio (r = 0.375, P &lt; 0.001) as well as fetal weight (r = 0.389, P &lt; 0.001) but not placental weight. Cord IGF-I concentration was positively associated with fetal weight (r = 0.405, P &lt; 0.001) and placental weight (r = 0.400, P &lt; 0.001) but not F/P weight ratio. In multiregression analysis, only APN concentration resulted in a significant determinant of F/P weight ratio among variables (β = 0.376, P &lt; 0.001).</jats:p> <jats:p>Conclusions: In cord hyperadiponectinemia, fetuses tend to be disproportionately larger for their placental weight and vice versa in cord hypoadiponectinemia. APN is shown to be the first biomarker positively associated with F/P weight ratio.</jats:p>

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