α-Melanocyte-Stimulating Hormone Inhibits Allergic Airway Inflammation

DOI PDF 被引用文献1件
  • Ulrike Raap
    Department of Clinical Chemistry and Molecular Diagnostics, Philipps-University Marburg , Marburg ,
  • Thomas Brzoska
    Department of Dermatology, Ludwig-Boltzmann Institute, University Muenster , Muenster ,
  • Sirius Sohl
    Department of Clinical Chemistry and Molecular Diagnostics, Philipps-University Marburg , Marburg ,
  • Günter Päth
    Department of Clinical Chemistry and Molecular Diagnostics, Philipps-University Marburg , Marburg ,
  • Jörg Emmel
    Department of Clinical Chemistry and Molecular Diagnostics, Philipps-University Marburg , Marburg ,
  • Udo Herz
    Department of Clinical Chemistry and Molecular Diagnostics, Philipps-University Marburg , Marburg ,
  • Armin Braun
    Department of Clinical Chemistry and Molecular Diagnostics, Philipps-University Marburg , Marburg ,
  • Thomas Luger
    Department of Dermatology, Ludwig-Boltzmann Institute, University Muenster , Muenster ,
  • Harald Renz
    Department of Clinical Chemistry and Molecular Diagnostics, Philipps-University Marburg , Marburg ,

書誌事項

公開日
2003-07-01
権利情報
  • https://academic.oup.com/pages/standard-publication-reuse-rights
DOI
  • 10.4049/jimmunol.171.1.353
公開者
Oxford University Press (OUP)

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<jats:title>Abstract</jats:title> <jats:p>α-Melanocyte-stimulating hormone (α-MSH) is a neuropeptide controlling melanogenesis in pigmentary cells. In addition, its potent immunomodulatory and immunosuppressive activity has been recently described in cutaneous inflammatory disorders. Whether α-MSH is also produced in the lung and might play a role in the pathogenesis of inflammatory lung conditions, including allergic bronchial asthma, is unknown. Production and functional role of α-MSH were investigated in a murine model of allergic airway inflammation. α-MSH production was detected in bronchoalveolar lavage fluids. Although aerosol challenges stimulate α-MSH production in nonsensitized mice, this rapid and marked stimulation was absent in allergic animals. Treatment of allergic mice with α-MSH resulted in suppression of airway inflammation. These effects were mediated via IL-10 production, because IL-10 knockout mice were resistant to α-MSH treatment. This study provides evidence for a novel function of α-MSH linking neuroimmune functions in allergic airway inflammation.</jats:p>

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