The melatonin receptor subtype MT<sub>2</sub> is present in the human cardiovascular system

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公開日
2003-06-16
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1034/j.1600-079x.2003.00051.x
公開者
Wiley

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<jats:p><jats:bold>Abstract:</jats:bold> We showed that the melatonin receptor subtype, MT<jats:sub>1</jats:sub>, is expressed in healthy and diseased human coronary arteries. As studies in experimental animals suggest that the MT<jats:sub>2</jats:sub> melatonin receptor subtype is also present in the vasculature, we investigated whether the MT<jats:sub>2</jats:sub> is expressed in human aorta and coronary arteries. Additionally, MT<jats:sub>2</jats:sub> expression in human ventricular specimens was analysed, as melatonin was shown to affect myocyte function. Expression of the MT<jats:sub>2</jats:sub>‐receptor was studied in sections of isolated coronary arteries, aorta and left ventricular specimens from healthy heart donors (control) and patients with dilated or ischemic cardiomyopathy. MT<jats:sub>2</jats:sub> expression was found by reverse transcriptase (RT)‐nested‐polymerase chain reaction (PCR) in all of the specimens (aorta, left ventricle and coronary arteries) derived from controls. Also, visible evidence for receptor expression was found in 12 of 15 samples from cardiomyopathy patients and 10 of 15 of coronary heart disease patients. Additionally, the expression of MT<jats:sub>2</jats:sub>‐receptor between aorta, left ventricle and coronary arteries varied among the individuals, some of them showing highest expression in the aorta while in others principal expression sites were coronary arteries or left ventricles. In conclusion, the MT<jats:sub>2</jats:sub>‐receptor subtype is present in human arteries and left ventricles and it is suggested that in coronary heart disease MT<jats:sub>2</jats:sub>‐receptor expression is altered. Furthermore, there is evidence for heterogeneous MT<jats:sub>2</jats:sub> expression patterns in individual patients.</jats:p>

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