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- Joseph B. Bolen
- DNAX Research Institute, Palo Alto, California 94304
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- Joan S. Brugge
- DNAX Research Institute, Palo Alto, California 94304
書誌事項
- 公開日
- 1997-04
- DOI
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- 10.1146/annurev.immunol.15.1.371
- 公開者
- Annual Reviews
この論文をさがす
説明
<jats:p>▪ Abstract Intracellular signal transduction following the extracellular ligation of a wide variety of different types of surface molecules on leukocytes involves the activation of protein tyrosine kinases. The dependence of successful intracellular signaling on the functions of the nontransmembrane class of protein tyrosine kinases coupled with the cell type–specific expression patterns for several of these enzymes makes them appealing targets for therapeutic intervention. Development of drugs that can interfere with the catalytic functions of the nontransmembrane protein tyrosine kinases or that can disrupt critical interactions with regulatory molecules and/or substrates should find clinical applications in the treatment of allergic diseases, autoimmunity, transplantation rejection, and cancer.</jats:p>
収録刊行物
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- Annual Review of Immunology
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Annual Review of Immunology 15 (1), 371-404, 1997-04
Annual Reviews
