Adding New Chemistries to the Genetic Code

書誌事項

公開日
2010-06-07
DOI
  • 10.1146/annurev.biochem.052308.105824
公開者
Annual Reviews

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説明

<jats:p> The development of new orthogonal aminoacyl-tRNA synthetase/tRNA pairs has led to the addition of approximately 70 unnatural amino acids (UAAs) to the genetic codes of Escherichia coli, yeast, and mammalian cells. These UAAs represent a wide range of structures and functions not found in the canonical 20 amino acids and thus provide new opportunities to generate proteins with enhanced or novel properties and probes of protein structure and function. </jats:p>

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