Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells
-
- Medha M. Pathak
- Departments of aPhysiology and Biophysics,
-
- Jamison L. Nourse
- Neurology, and
-
- Truc Tran
- Departments of aPhysiology and Biophysics,
-
- Jennifer Hwe
- Departments of aPhysiology and Biophysics,
-
- Janahan Arulmoli
- Biomedical Engineering and
-
- Dai Trang T. Le
- Departments of aPhysiology and Biophysics,
-
- Elena Bernardis
- Section of Dermatology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104
-
- Lisa A. Flanagan
- Neurology, and
-
- Francesco Tombola
- Departments of aPhysiology and Biophysics,
Description
<jats:title>Significance</jats:title> <jats:p>Stem cells make lineage-choice decisions based on a combination of internal and external signals, including mechanical cues from the surrounding environment. Here we show that Piezo1, an ion channel opened by membrane tension, plays an important role in transducing matrix mechanical information to intracellular pathways affecting differentiation in neural stem cells. Piezo1 activity influences whether neural stem cells differentiate along a neuronal or astrocytic lineage. One of the barriers to successful neural stem cell transplantation therapy for neurological disorders lies in directing the fate of transplanted cells. Pharmacological agents aimed at modulating Piezo1 activity may be useful in directing the fate of transplanted neural stem cells toward the desired lineage.</jats:p>
Journal
-
- Proceedings of the National Academy of Sciences
-
Proceedings of the National Academy of Sciences 111 (45), 16148-16153, 2014-10-27
Proceedings of the National Academy of Sciences
- Tweet
Details 詳細情報について
-
- CRID
- 1361699994019357184
-
- ISSN
- 10916490
- 00278424
-
- Data Source
-
- Crossref