A Broad-Spectrum Chemokine Antagonist Encoded by Kaposi's Sarcoma-Associated Herpesvirus

DOI Web Site 8 Citations
  • Thomas N. Kledal
    T. N. Kledal, M. M. Rosenkilde, T. W. Schwartz, Laboratory for Molecular Pharmacology, Institute of Pharmacology, Panum Institute, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Mette M. Rosenkilde
    T. N. Kledal, M. M. Rosenkilde, T. W. Schwartz, Laboratory for Molecular Pharmacology, Institute of Pharmacology, Panum Institute, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Florence Coulin
    T. N. Kledal, M. M. Rosenkilde, T. W. Schwartz, Laboratory for Molecular Pharmacology, Institute of Pharmacology, Panum Institute, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Graham Simmons
    T. N. Kledal, M. M. Rosenkilde, T. W. Schwartz, Laboratory for Molecular Pharmacology, Institute of Pharmacology, Panum Institute, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Anders H. Johnsen
    T. N. Kledal, M. M. Rosenkilde, T. W. Schwartz, Laboratory for Molecular Pharmacology, Institute of Pharmacology, Panum Institute, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Sami Alouani
    T. N. Kledal, M. M. Rosenkilde, T. W. Schwartz, Laboratory for Molecular Pharmacology, Institute of Pharmacology, Panum Institute, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Christine A. Power
    T. N. Kledal, M. M. Rosenkilde, T. W. Schwartz, Laboratory for Molecular Pharmacology, Institute of Pharmacology, Panum Institute, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Hans R. Lüttichau
    T. N. Kledal, M. M. Rosenkilde, T. W. Schwartz, Laboratory for Molecular Pharmacology, Institute of Pharmacology, Panum Institute, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Jan Gerstoft
    T. N. Kledal, M. M. Rosenkilde, T. W. Schwartz, Laboratory for Molecular Pharmacology, Institute of Pharmacology, Panum Institute, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Paul R. Clapham
    T. N. Kledal, M. M. Rosenkilde, T. W. Schwartz, Laboratory for Molecular Pharmacology, Institute of Pharmacology, Panum Institute, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Ian Clark-Lewis
    T. N. Kledal, M. M. Rosenkilde, T. W. Schwartz, Laboratory for Molecular Pharmacology, Institute of Pharmacology, Panum Institute, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Timothy N. C. Wells
    T. N. Kledal, M. M. Rosenkilde, T. W. Schwartz, Laboratory for Molecular Pharmacology, Institute of Pharmacology, Panum Institute, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Thue W. Schwartz
    T. N. Kledal, M. M. Rosenkilde, T. W. Schwartz, Laboratory for Molecular Pharmacology, Institute of Pharmacology, Panum Institute, University of Copenhagen, DK-2200 Copenhagen, Denmark.

Description

<jats:p>Kaposi's sarcoma–associated herpesvirus encodes a chemokine called vMIP-II. This protein displayed a broader spectrum of receptor activities than any mammalian chemokine as it bound with high affinity to a number of both CC and CXC chemokine receptors. Binding of vMIP-II, however, was not associated with the normal, rapid mobilization of calcium from intracellular stores; instead, it blocked calcium mobilization induced by endogenous chemokines. In freshly isolated human monocytes the virally encoded vMIP-II acted as a potent and efficient antagonist of chemotaxis induced by chemokines. Because vMIP-II could inhibit cell entry of human immunodeficiency virus (HIV) mediated through CCR3 and CCR5 as well as CXCR4, this protein may serve as a lead for development of broad-spectrum anti-HIV agents.</jats:p>

Journal

  • Science

    Science 277 (5332), 1656-1659, 1997-09-12

    American Association for the Advancement of Science (AAAS)

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