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- Pedro R. Cutillas
- Analytical Signalling Laboratory, Centre for Cell Signalling, Institute of Cancer, Bart's and the London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, U.K.
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- Claus Jørgensen
- Section of Cell and Molecular Biology, Cell Communication Team, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, U.K.
書誌事項
- 公開日
- 2011-02-11
- DOI
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- 10.1042/bj20101974
- 公開者
- Portland Press Ltd.
この論文をさがす
説明
<jats:p>MS (mass spectrometry) techniques are rapidly evolving to high levels of performance and robustness. This is allowing the application of these methods to the interrogation of signalling networks with unprecedented depth and accuracy. In the present review we discuss how MS-based multiplex quantification of kinase activities and phosphoproteomics provide complementary means to assess biological signalling activity. In addition, we discuss how a wider application of these analytical concepts to quantify kinase signalling will result in a more comprehensive understanding of normal and disease biology at the system level.</jats:p>
収録刊行物
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- Biochemical Journal
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Biochemical Journal 434 (2), 189-199, 2011-02-11
Portland Press Ltd.
