A Possible Change Process of Inflammatory Cytokines in the Prolonged Chronic Stress and Its Ultimate Implications for Health
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- Rui Tian
- Department of Psychology, Zhejiang Sci-Tech University, 579 Mailbox, Hangzhou 310018, China
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- Gonglin Hou
- Department of Psychology, Zhejiang Sci-Tech University, 579 Mailbox, Hangzhou 310018, China
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- Dan Li
- Department of Psychology, Zhejiang Sci-Tech University, 579 Mailbox, Hangzhou 310018, China
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- Ti-Fei Yuan
- Department of Psychology, Nanjing Normal University, Nanjing 210097, China
書誌事項
- 公開日
- 2014
- 権利情報
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- http://creativecommons.org/licenses/by/3.0/
- DOI
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- 10.1155/2014/780616
- 公開者
- Wiley
この論文をさがす
説明
<jats:p>Sustained stress triggers series of changes in the brain and the body. At the early stage of stress, the activated hypothalamus-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS) axis can upregulate the levels of glucocorticoid (GCs) and catecholamines (CAs), respectively, and then they in turn inhibit the secretion of proinflammatory cytokines directly or indirectly while promoting the secretion of anti-inflammatory cytokines. At the prolonged stage, the sustained activated HPA demonstrates cortisol-resistance. At the same time, the inflammation related transcription pathway, such as nuclear-factor kappa-B (NF-<jats:italic>κ</jats:italic>B) signaling, may be inhibited. Additionally, the inflammatory cytokines mediate a negative feedback regulation on themselves. Collectively, these regulations may increase the proinflammatory cytokines while decreasing the anti-inflammatory cytokines. This may further activate NF-<jats:italic>κ</jats:italic>B and increase the proinflammation cytokines, which in turn reduce the inflammatory responses, contributing to various diseases.</jats:p>
収録刊行物
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- The Scientific World Journal
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The Scientific World Journal 2014 1-8, 2014
Wiley