Methyltransferase‐Directed Labeling of Biomolecules and its Applications

DOI Web Site Web Site 被引用文献2件
  • Jochem Deen
    Laboratory of Nanoscale Biology School of Engineering, EPFL, STI IBI-STI LBEN BM 5134 (Bâtiment BM) Station 17 CH-1015 Lausanne Switzerland
  • Charlotte Vranken
    Laboratory of Photochemistry and Spectroscopy, Department of Chemistry KU Leuven Celestijnenlaan 200F B-3001 Heverlee Belgium
  • Volker Leen
    Laboratory of Photochemistry and Spectroscopy, Department of Chemistry KU Leuven Celestijnenlaan 200F B-3001 Heverlee Belgium
  • Robert K. Neely
    School of Chemistry University of Birmingham Edgbaston Birmingham B15 2TT UK
  • Kris P. F. Janssen
    Laboratory of Photochemistry and Spectroscopy, Department of Chemistry KU Leuven Celestijnenlaan 200F B-3001 Heverlee Belgium
  • Johan Hofkens
    Laboratory of Photochemistry and Spectroscopy, Department of Chemistry KU Leuven Celestijnenlaan 200F B-3001 Heverlee Belgium

書誌事項

公開日
2017-04-10
権利情報
  • http://creativecommons.org/licenses/by-nc-nd/4.0/
DOI
  • 10.1002/anie.201608625
公開者
Wiley

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説明

<jats:title>Abstract</jats:title><jats:p>Methyltransferases (MTases) form a large family of enzymes that methylate a diverse set of targets, ranging from the three major biopolymers to small molecules. Most of these MTases use the cofactor S‐adenosyl‐<jats:sc>l</jats:sc>‐Methionine (AdoMet) as a methyl source. In recent years, there have been significant efforts toward the development of AdoMet analogues with the aim of transferring moieties other than simple methyl groups. Two major classes of AdoMet analogues currently exist: doubly‐activated molecules and aziridine based molecules, each of which employs a different approach to achieve transalkylation rather than transmethylation. In this review, we discuss the various strategies for labelling and functionalizing biomolecules using AdoMet‐dependent MTases and AdoMet analogues. We cover the synthetic routes to AdoMet analogues, their stability in biological environments and their application in transalkylation reactions. Finally, some perspectives are presented for the potential use of AdoMet analogues in biology research, (epi)genetics and nanotechnology.</jats:p>

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