Randomized Comparison of Sirolimus-Eluting and Everolimus-Eluting Coronary Stents in the Treatment of Total Coronary Occlusions

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  • Raul Moreno
    From the Hospital Universitario La Paz, Madrid, Spain (R.M., A.S.-R., G.G., S.J.-V., E.L.d.S., L.C., I.P., J.-L.L.-S.); Hospital Clinico, Madrid, Spain (E.G.); Hospital de Santa Cruz, Lisbon, Portugal (R.T., M.A.); Hospital de Galdakao, Bilbao, Spain (J.-R.R.); Hospital de Santo Antonio, Porto, Portugal (H.C.C.); Hospital Puerta de Hierro, Majadahonda, Spain (F.J.G.); Hospital Virgen de la Salud, Toledo, Spain (J.M.); Hospital German Trias I Pujol, Badalona, Spain (J.Mauri); Hospital Santa Creu I...
  • Eulogio García
    From the Hospital Universitario La Paz, Madrid, Spain (R.M., A.S.-R., G.G., S.J.-V., E.L.d.S., L.C., I.P., J.-L.L.-S.); Hospital Clinico, Madrid, Spain (E.G.); Hospital de Santa Cruz, Lisbon, Portugal (R.T., M.A.); Hospital de Galdakao, Bilbao, Spain (J.-R.R.); Hospital de Santo Antonio, Porto, Portugal (H.C.C.); Hospital Puerta de Hierro, Majadahonda, Spain (F.J.G.); Hospital Virgen de la Salud, Toledo, Spain (J.M.); Hospital German Trias I Pujol, Badalona, Spain (J.Mauri); Hospital Santa Creu I...
  • Rui Teles
    From the Hospital Universitario La Paz, Madrid, Spain (R.M., A.S.-R., G.G., S.J.-V., E.L.d.S., L.C., I.P., J.-L.L.-S.); Hospital Clinico, Madrid, Spain (E.G.); Hospital de Santa Cruz, Lisbon, Portugal (R.T., M.A.); Hospital de Galdakao, Bilbao, Spain (J.-R.R.); Hospital de Santo Antonio, Porto, Portugal (H.C.C.); Hospital Puerta de Hierro, Majadahonda, Spain (F.J.G.); Hospital Virgen de la Salud, Toledo, Spain (J.M.); Hospital German Trias I Pujol, Badalona, Spain (J.Mauri); Hospital Santa Creu I...
  • Jose-Ramon Rumoroso
    From the Hospital Universitario La Paz, Madrid, Spain (R.M., A.S.-R., G.G., S.J.-V., E.L.d.S., L.C., I.P., J.-L.L.-S.); Hospital Clinico, Madrid, Spain (E.G.); Hospital de Santa Cruz, Lisbon, Portugal (R.T., M.A.); Hospital de Galdakao, Bilbao, Spain (J.-R.R.); Hospital de Santo Antonio, Porto, Portugal (H.C.C.); Hospital Puerta de Hierro, Majadahonda, Spain (F.J.G.); Hospital Virgen de la Salud, Toledo, Spain (J.M.); Hospital German Trias I Pujol, Badalona, Spain (J.Mauri); Hospital Santa Creu I...
  • Henrique Cyrne Carvalho
    From the Hospital Universitario La Paz, Madrid, Spain (R.M., A.S.-R., G.G., S.J.-V., E.L.d.S., L.C., I.P., J.-L.L.-S.); Hospital Clinico, Madrid, Spain (E.G.); Hospital de Santa Cruz, Lisbon, Portugal (R.T., M.A.); Hospital de Galdakao, Bilbao, Spain (J.-R.R.); Hospital de Santo Antonio, Porto, Portugal (H.C.C.); Hospital Puerta de Hierro, Majadahonda, Spain (F.J.G.); Hospital Virgen de la Salud, Toledo, Spain (J.M.); Hospital German Trias I Pujol, Badalona, Spain (J.Mauri); Hospital Santa Creu I...
  • Francisco Javier Goicolea
    From the Hospital Universitario La Paz, Madrid, Spain (R.M., A.S.-R., G.G., S.J.-V., E.L.d.S., L.C., I.P., J.-L.L.-S.); Hospital Clinico, Madrid, Spain (E.G.); Hospital de Santa Cruz, Lisbon, Portugal (R.T., M.A.); Hospital de Galdakao, Bilbao, Spain (J.-R.R.); Hospital de Santo Antonio, Porto, Portugal (H.C.C.); Hospital Puerta de Hierro, Majadahonda, Spain (F.J.G.); Hospital Virgen de la Salud, Toledo, Spain (J.M.); Hospital German Trias I Pujol, Badalona, Spain (J.Mauri); Hospital Santa Creu I...
  • José Moreu
    From the Hospital Universitario La Paz, Madrid, Spain (R.M., A.S.-R., G.G., S.J.-V., E.L.d.S., L.C., I.P., J.-L.L.-S.); Hospital Clinico, Madrid, Spain (E.G.); Hospital de Santa Cruz, Lisbon, Portugal (R.T., M.A.); Hospital de Galdakao, Bilbao, Spain (J.-R.R.); Hospital de Santo Antonio, Porto, Portugal (H.C.C.); Hospital Puerta de Hierro, Majadahonda, Spain (F.J.G.); Hospital Virgen de la Salud, Toledo, Spain (J.M.); Hospital German Trias I Pujol, Badalona, Spain (J.Mauri); Hospital Santa Creu I...
  • Josefa Mauri
    From the Hospital Universitario La Paz, Madrid, Spain (R.M., A.S.-R., G.G., S.J.-V., E.L.d.S., L.C., I.P., J.-L.L.-S.); Hospital Clinico, Madrid, Spain (E.G.); Hospital de Santa Cruz, Lisbon, Portugal (R.T., M.A.); Hospital de Galdakao, Bilbao, Spain (J.-R.R.); Hospital de Santo Antonio, Porto, Portugal (H.C.C.); Hospital Puerta de Hierro, Majadahonda, Spain (F.J.G.); Hospital Virgen de la Salud, Toledo, Spain (J.M.); Hospital German Trias I Pujol, Badalona, Spain (J.Mauri); Hospital Santa Creu I...
  • Manel Sabaté
    From the Hospital Universitario La Paz, Madrid, Spain (R.M., A.S.-R., G.G., S.J.-V., E.L.d.S., L.C., I.P., J.-L.L.-S.); Hospital Clinico, Madrid, Spain (E.G.); Hospital de Santa Cruz, Lisbon, Portugal (R.T., M.A.); Hospital de Galdakao, Bilbao, Spain (J.-R.R.); Hospital de Santo Antonio, Porto, Portugal (H.C.C.); Hospital Puerta de Hierro, Majadahonda, Spain (F.J.G.); Hospital Virgen de la Salud, Toledo, Spain (J.M.); Hospital German Trias I Pujol, Badalona, Spain (J.Mauri); Hospital Santa Creu I...
  • Vicente Mainar
    From the Hospital Universitario La Paz, Madrid, Spain (R.M., A.S.-R., G.G., S.J.-V., E.L.d.S., L.C., I.P., J.-L.L.-S.); Hospital Clinico, Madrid, Spain (E.G.); Hospital de Santa Cruz, Lisbon, Portugal (R.T., M.A.); Hospital de Galdakao, Bilbao, Spain (J.-R.R.); Hospital de Santo Antonio, Porto, Portugal (H.C.C.); Hospital Puerta de Hierro, Majadahonda, Spain (F.J.G.); Hospital Virgen de la Salud, Toledo, Spain (J.M.); Hospital German Trias I Pujol, Badalona, Spain (J.Mauri); Hospital Santa Creu I...
  • Lino Patricio
    From the Hospital Universitario La Paz, Madrid, Spain (R.M., A.S.-R., G.G., S.J.-V., E.L.d.S., L.C., I.P., J.-L.L.-S.); Hospital Clinico, Madrid, Spain (E.G.); Hospital de Santa Cruz, Lisbon, Portugal (R.T., M.A.); Hospital de Galdakao, Bilbao, Spain (J.-R.R.); Hospital de Santo Antonio, Porto, Portugal (H.C.C.); Hospital Puerta de Hierro, Majadahonda, Spain (F.J.G.); Hospital Virgen de la Salud, Toledo, Spain (J.M.); Hospital German Trias I Pujol, Badalona, Spain (J.Mauri); Hospital Santa Creu I...
  • Mariano Valdés
    From the Hospital Universitario La Paz, Madrid, Spain (R.M., A.S.-R., G.G., S.J.-V., E.L.d.S., L.C., I.P., J.-L.L.-S.); Hospital Clinico, Madrid, Spain (E.G.); Hospital de Santa Cruz, Lisbon, Portugal (R.T., M.A.); Hospital de Galdakao, Bilbao, Spain (J.-R.R.); Hospital de Santo Antonio, Porto, Portugal (H.C.C.); Hospital Puerta de Hierro, Majadahonda, Spain (F.J.G.); Hospital Virgen de la Salud, Toledo, Spain (J.M.); Hospital German Trias I Pujol, Badalona, Spain (J.Mauri); Hospital Santa Creu I...
  • Felipez Fernández Vázquez
    From the Hospital Universitario La Paz, Madrid, Spain (R.M., A.S.-R., G.G., S.J.-V., E.L.d.S., L.C., I.P., J.-L.L.-S.); Hospital Clinico, Madrid, Spain (E.G.); Hospital de Santa Cruz, Lisbon, Portugal (R.T., M.A.); Hospital de Galdakao, Bilbao, Spain (J.-R.R.); Hospital de Santo Antonio, Porto, Portugal (H.C.C.); Hospital Puerta de Hierro, Majadahonda, Spain (F.J.G.); Hospital Virgen de la Salud, Toledo, Spain (J.M.); Hospital German Trias I Pujol, Badalona, Spain (J.Mauri); Hospital Santa Creu I...
  • Angel Sánchez-Recalde
    From the Hospital Universitario La Paz, Madrid, Spain (R.M., A.S.-R., G.G., S.J.-V., E.L.d.S., L.C., I.P., J.-L.L.-S.); Hospital Clinico, Madrid, Spain (E.G.); Hospital de Santa Cruz, Lisbon, Portugal (R.T., M.A.); Hospital de Galdakao, Bilbao, Spain (J.-R.R.); Hospital de Santo Antonio, Porto, Portugal (H.C.C.); Hospital Puerta de Hierro, Majadahonda, Spain (F.J.G.); Hospital Virgen de la Salud, Toledo, Spain (J.M.); Hospital German Trias I Pujol, Badalona, Spain (J.Mauri); Hospital Santa Creu I...
  • Guillermo Galeote
    From the Hospital Universitario La Paz, Madrid, Spain (R.M., A.S.-R., G.G., S.J.-V., E.L.d.S., L.C., I.P., J.-L.L.-S.); Hospital Clinico, Madrid, Spain (E.G.); Hospital de Santa Cruz, Lisbon, Portugal (R.T., M.A.); Hospital de Galdakao, Bilbao, Spain (J.-R.R.); Hospital de Santo Antonio, Porto, Portugal (H.C.C.); Hospital Puerta de Hierro, Majadahonda, Spain (F.J.G.); Hospital Virgen de la Salud, Toledo, Spain (J.M.); Hospital German Trias I Pujol, Badalona, Spain (J.Mauri); Hospital Santa Creu I...
  • Santiago Jimenez-Valero
    From the Hospital Universitario La Paz, Madrid, Spain (R.M., A.S.-R., G.G., S.J.-V., E.L.d.S., L.C., I.P., J.-L.L.-S.); Hospital Clinico, Madrid, Spain (E.G.); Hospital de Santa Cruz, Lisbon, Portugal (R.T., M.A.); Hospital de Galdakao, Bilbao, Spain (J.-R.R.); Hospital de Santo Antonio, Porto, Portugal (H.C.C.); Hospital Puerta de Hierro, Majadahonda, Spain (F.J.G.); Hospital Virgen de la Salud, Toledo, Spain (J.M.); Hospital German Trias I Pujol, Badalona, Spain (J.Mauri); Hospital Santa Creu I...
  • Manuel Almeida
    From the Hospital Universitario La Paz, Madrid, Spain (R.M., A.S.-R., G.G., S.J.-V., E.L.d.S., L.C., I.P., J.-L.L.-S.); Hospital Clinico, Madrid, Spain (E.G.); Hospital de Santa Cruz, Lisbon, Portugal (R.T., M.A.); Hospital de Galdakao, Bilbao, Spain (J.-R.R.); Hospital de Santo Antonio, Porto, Portugal (H.C.C.); Hospital Puerta de Hierro, Majadahonda, Spain (F.J.G.); Hospital Virgen de la Salud, Toledo, Spain (J.M.); Hospital German Trias I Pujol, Badalona, Spain (J.Mauri); Hospital Santa Creu I...
  • Esteban Lopez de Sa
    From the Hospital Universitario La Paz, Madrid, Spain (R.M., A.S.-R., G.G., S.J.-V., E.L.d.S., L.C., I.P., J.-L.L.-S.); Hospital Clinico, Madrid, Spain (E.G.); Hospital de Santa Cruz, Lisbon, Portugal (R.T., M.A.); Hospital de Galdakao, Bilbao, Spain (J.-R.R.); Hospital de Santo Antonio, Porto, Portugal (H.C.C.); Hospital Puerta de Hierro, Majadahonda, Spain (F.J.G.); Hospital Virgen de la Salud, Toledo, Spain (J.M.); Hospital German Trias I Pujol, Badalona, Spain (J.Mauri); Hospital Santa Creu I...
  • Luis Calvo
    From the Hospital Universitario La Paz, Madrid, Spain (R.M., A.S.-R., G.G., S.J.-V., E.L.d.S., L.C., I.P., J.-L.L.-S.); Hospital Clinico, Madrid, Spain (E.G.); Hospital de Santa Cruz, Lisbon, Portugal (R.T., M.A.); Hospital de Galdakao, Bilbao, Spain (J.-R.R.); Hospital de Santo Antonio, Porto, Portugal (H.C.C.); Hospital Puerta de Hierro, Majadahonda, Spain (F.J.G.); Hospital Virgen de la Salud, Toledo, Spain (J.M.); Hospital German Trias I Pujol, Badalona, Spain (J.Mauri); Hospital Santa Creu I...
  • Ignacio Plaza
    From the Hospital Universitario La Paz, Madrid, Spain (R.M., A.S.-R., G.G., S.J.-V., E.L.d.S., L.C., I.P., J.-L.L.-S.); Hospital Clinico, Madrid, Spain (E.G.); Hospital de Santa Cruz, Lisbon, Portugal (R.T., M.A.); Hospital de Galdakao, Bilbao, Spain (J.-R.R.); Hospital de Santo Antonio, Porto, Portugal (H.C.C.); Hospital Puerta de Hierro, Majadahonda, Spain (F.J.G.); Hospital Virgen de la Salud, Toledo, Spain (J.M.); Hospital German Trias I Pujol, Badalona, Spain (J.Mauri); Hospital Santa Creu I...
  • Jose-Luis Lopez-Sendón
    From the Hospital Universitario La Paz, Madrid, Spain (R.M., A.S.-R., G.G., S.J.-V., E.L.d.S., L.C., I.P., J.-L.L.-S.); Hospital Clinico, Madrid, Spain (E.G.); Hospital de Santa Cruz, Lisbon, Portugal (R.T., M.A.); Hospital de Galdakao, Bilbao, Spain (J.-R.R.); Hospital de Santo Antonio, Porto, Portugal (H.C.C.); Hospital Puerta de Hierro, Majadahonda, Spain (F.J.G.); Hospital Virgen de la Salud, Toledo, Spain (J.M.); Hospital German Trias I Pujol, Badalona, Spain (J.Mauri); Hospital Santa Creu I...
  • Jose-Luis R. Martín
    From the Hospital Universitario La Paz, Madrid, Spain (R.M., A.S.-R., G.G., S.J.-V., E.L.d.S., L.C., I.P., J.-L.L.-S.); Hospital Clinico, Madrid, Spain (E.G.); Hospital de Santa Cruz, Lisbon, Portugal (R.T., M.A.); Hospital de Galdakao, Bilbao, Spain (J.-R.R.); Hospital de Santo Antonio, Porto, Portugal (H.C.C.); Hospital Puerta de Hierro, Majadahonda, Spain (F.J.G.); Hospital Virgen de la Salud, Toledo, Spain (J.M.); Hospital German Trias I Pujol, Badalona, Spain (J.Mauri); Hospital Santa Creu I...

書誌事項

タイトル別名
  • Results From the Chronic Coronary Occlusion Treated by Everolimus-eluting Stent Randomized Trial
公開日
2013-02
DOI
  • 10.1161/circinterventions.112.000076
公開者
Ovid Technologies (Wolters Kluwer Health)

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説明

<jats:sec> <jats:title>Background—</jats:title> <jats:p>Patients with coronary total occlusions are at especially high risk for restenosis and new revascularizations. Sirolimus-eluting stents dramatically improved the clinical outcome of this subset of patients in randomized trials, but other drug-eluting stents, mainly the everolimus-eluting stent (currently the most frequently used stent), have not yet been evaluated in patients with coronary total occlusions. The objective was to compare the second-generation everolimus-eluting stent with the first-generation sirolimus-eluting stent in patients with coronary total occlusions.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods and Results—</jats:title> <jats:p> A total of 207 patients with coronary total occlusions and estimated time since occlusion >2 weeks were randomized to everolimus- or sirolimus-eluting stent. The primary end point was in-stent late loss at 9-month angiographic follow-up (noninferiority trial). Clinical follow-up was performed at 1 and 12 months. In-stent late loss at 9 months was 0.29±0.60 versus 0.13±0.69 mm in patients allocated to sirolimus- and everolimus-eluting stent, respectively. The observed difference in in-stent late loss between both groups was –0.16 mm (95% confidence interval, 0.04 to –0.36 mm; <jats:italic>P</jats:italic> for noninferiority <0.01). The rate of binary angiographic restenosis was 10.8% and 9.1% in patients allocated to sirolimus- and everolimus-eluting stent, respectively ( <jats:italic>P</jats:italic> =0.709), whereas the rate of vessel reocclusion was 3.2% and 1.1%, respectively ( <jats:italic>P</jats:italic> =0.339). At 12 months, the rate of major adverse events was 15.9% versus 11.1% with sirolimus- and everolimus-eluting stent, respectively ( <jats:italic>P</jats:italic> =0.335), and probable or definitive stent thrombosis occurred in 3.0% and 0.0% of patients, respectively ( <jats:italic>P</jats:italic> =0.075). </jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions—</jats:title> <jats:p>In patients with coronary total occlusions, everolimus-eluting stent is as effective as sirolimus-eluting stent.</jats:p> </jats:sec> <jats:sec> <jats:title>Clinical Trial Registration—</jats:title> <jats:p> URL: <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.clinicaltrials.gov">http://www.clinicaltrials.gov</jats:ext-link> . Unique identifier: NCT00793221. </jats:p> </jats:sec>

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