The Role of MicroRNAs in Myocardial Infarction: From Molecular Mechanism to Clinical Application
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- Teng Sun
- Institute for Translational Medicine, Qingdao University, Qingdao 266021, China
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- Yan-Han Dong
- Institute for Translational Medicine, Qingdao University, Qingdao 266021, China
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- Wei Du
- Institute for Translational Medicine, Qingdao University, Qingdao 266021, China
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- Chun-Ying Shi
- Institute for Translational Medicine, Qingdao University, Qingdao 266021, China
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- Kun Wang
- Institute for Translational Medicine, Qingdao University, Qingdao 266021, China
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- Muhammad-Akram Tariq
- Institute for Translational Medicine, Qingdao University, Qingdao 266021, China
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- Jian-Xun Wang
- Institute for Translational Medicine, Qingdao University, Qingdao 266021, China
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- Pei-Feng Li
- Institute for Translational Medicine, Qingdao University, Qingdao 266021, China
書誌事項
- 公開日
- 2017-03-31
- 権利情報
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- https://creativecommons.org/licenses/by/4.0/
- DOI
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- 10.3390/ijms18040745
- 公開者
- MDPI AG
説明
<jats:p>MicroRNAs (miRNAs) are a class of small single-stranded and highly conserved non-coding RNAs, which are closely linked to cardiac disorders such as myocardial infarction (MI), cardiomyocyte hypertrophy, and heart failure. A growing number of studies have demonstrated that miRNAs determine the fate of the heart by regulating cardiac cell death and regeneration after MI. A deep understanding of the pathophysiology of miRNA dependent regulatory pathways in these processes is required. The role of miRNAs as diagnostic, prognostic, and therapeutic targets also needs to be explored in order to utilize them in clinical settings. This review summarizes the role of miRNAs in myocardial infarction and focuses mainly on their influence on cardiomyocyte regeneration and cell death including apoptosis, necrosis, and autophagy. In addition, the targets of pro- and anti-MI miRNAs are comparatively described. In particular, the possibilities of miRNA-based diagnostic and therapeutic strategies for myocardial infarction are discussed in this review.</jats:p>
収録刊行物
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- International Journal of Molecular Sciences
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International Journal of Molecular Sciences 18 (4), 745-, 2017-03-31
MDPI AG