Breast and Ovarian Cancer Risks Due to Inherited Mutations in <i>BRCA1</i> and <i>BRCA2</i>

DOI Web Site 18 Citations
  • Mary-Claire King
    Departments of Medicine and Genome Sciences, University of Washington, Seattle, WA 98195, USA.
  • Joan H. Marks
    Departments of Medicine and Genome Sciences, University of Washington, Seattle, WA 98195, USA.
  • Jessica B. Mandell
    Departments of Medicine and Genome Sciences, University of Washington, Seattle, WA 98195, USA.

Description

<jats:p> Risks of breast and ovarian cancer were determined for Ashkenazi Jewish women with inherited mutations in the tumor suppressor genes <jats:italic>BRCA1</jats:italic> and <jats:italic>BRCA2</jats:italic> . We selected 1008 index cases, regardless of family history of cancer, and carried out molecular analysis across entire families. The lifetime risk of breast cancer among female mutation carriers was 82%, similar to risks in families with many cases. Risks appear to be increasing with time: Breast cancer risk by age 50 among mutation carriers born before 1940 was 24%, but among those born after 1940 it was 67%. Lifetime risks of ovarian cancer were 54% for <jats:italic>BRCA1</jats:italic> and 23% for <jats:italic>BRCA2</jats:italic> mutation carriers. Physical exercise and lack of obesity in adolescence were associated with significantly delayed breast cancer onset. </jats:p>

Journal

  • Science

    Science 302 (5645), 643-646, 2003-10-24

    American Association for the Advancement of Science (AAAS)

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