Mortality Reduction in Relation to Implantable Cardioverter Defibrillator Programming in the Multicenter Automatic Defibrillator Implantation Trial-Reduce Inappropriate Therapy (MADIT-RIT)

DOI Web Site 被引用文献3件
  • Anne-Christine Ruwald
    From the Heart Research Follow-up Program, University of Rochester Medical Center, NY (A.-C.R., A.J.M., V.K., M.H.R., D.T.H., H.K., S.M., C.A.B., M.W.B., W.Z.); Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (A.-C.R., M.H.R.); Division of Cardiology, Henry Ford Hospital, Detroit, MI (C.S.); Department of Medicine, University of Iowa Health Care, Iowa City (B.O.); St Luke’s and Roosevelt Hospitals, Departments of Medicine and Epidemiology, Columbia University, New York, NY ...
  • Claudio Schuger
    From the Heart Research Follow-up Program, University of Rochester Medical Center, NY (A.-C.R., A.J.M., V.K., M.H.R., D.T.H., H.K., S.M., C.A.B., M.W.B., W.Z.); Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (A.-C.R., M.H.R.); Division of Cardiology, Henry Ford Hospital, Detroit, MI (C.S.); Department of Medicine, University of Iowa Health Care, Iowa City (B.O.); St Luke’s and Roosevelt Hospitals, Departments of Medicine and Epidemiology, Columbia University, New York, NY ...
  • Arthur J. Moss
    From the Heart Research Follow-up Program, University of Rochester Medical Center, NY (A.-C.R., A.J.M., V.K., M.H.R., D.T.H., H.K., S.M., C.A.B., M.W.B., W.Z.); Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (A.-C.R., M.H.R.); Division of Cardiology, Henry Ford Hospital, Detroit, MI (C.S.); Department of Medicine, University of Iowa Health Care, Iowa City (B.O.); St Luke’s and Roosevelt Hospitals, Departments of Medicine and Epidemiology, Columbia University, New York, NY ...
  • Valentina Kutyifa
    From the Heart Research Follow-up Program, University of Rochester Medical Center, NY (A.-C.R., A.J.M., V.K., M.H.R., D.T.H., H.K., S.M., C.A.B., M.W.B., W.Z.); Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (A.-C.R., M.H.R.); Division of Cardiology, Henry Ford Hospital, Detroit, MI (C.S.); Department of Medicine, University of Iowa Health Care, Iowa City (B.O.); St Luke’s and Roosevelt Hospitals, Departments of Medicine and Epidemiology, Columbia University, New York, NY ...
  • Brian Olshansky
    From the Heart Research Follow-up Program, University of Rochester Medical Center, NY (A.-C.R., A.J.M., V.K., M.H.R., D.T.H., H.K., S.M., C.A.B., M.W.B., W.Z.); Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (A.-C.R., M.H.R.); Division of Cardiology, Henry Ford Hospital, Detroit, MI (C.S.); Department of Medicine, University of Iowa Health Care, Iowa City (B.O.); St Luke’s and Roosevelt Hospitals, Departments of Medicine and Epidemiology, Columbia University, New York, NY ...
  • Henry Greenberg
    From the Heart Research Follow-up Program, University of Rochester Medical Center, NY (A.-C.R., A.J.M., V.K., M.H.R., D.T.H., H.K., S.M., C.A.B., M.W.B., W.Z.); Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (A.-C.R., M.H.R.); Division of Cardiology, Henry Ford Hospital, Detroit, MI (C.S.); Department of Medicine, University of Iowa Health Care, Iowa City (B.O.); St Luke’s and Roosevelt Hospitals, Departments of Medicine and Epidemiology, Columbia University, New York, NY ...
  • David S. Cannom
    From the Heart Research Follow-up Program, University of Rochester Medical Center, NY (A.-C.R., A.J.M., V.K., M.H.R., D.T.H., H.K., S.M., C.A.B., M.W.B., W.Z.); Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (A.-C.R., M.H.R.); Division of Cardiology, Henry Ford Hospital, Detroit, MI (C.S.); Department of Medicine, University of Iowa Health Care, Iowa City (B.O.); St Luke’s and Roosevelt Hospitals, Departments of Medicine and Epidemiology, Columbia University, New York, NY ...
  • N.A. Mark Estes
    From the Heart Research Follow-up Program, University of Rochester Medical Center, NY (A.-C.R., A.J.M., V.K., M.H.R., D.T.H., H.K., S.M., C.A.B., M.W.B., W.Z.); Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (A.-C.R., M.H.R.); Division of Cardiology, Henry Ford Hospital, Detroit, MI (C.S.); Department of Medicine, University of Iowa Health Care, Iowa City (B.O.); St Luke’s and Roosevelt Hospitals, Departments of Medicine and Epidemiology, Columbia University, New York, NY ...
  • Martin H. Ruwald
    From the Heart Research Follow-up Program, University of Rochester Medical Center, NY (A.-C.R., A.J.M., V.K., M.H.R., D.T.H., H.K., S.M., C.A.B., M.W.B., W.Z.); Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (A.-C.R., M.H.R.); Division of Cardiology, Henry Ford Hospital, Detroit, MI (C.S.); Department of Medicine, University of Iowa Health Care, Iowa City (B.O.); St Luke’s and Roosevelt Hospitals, Departments of Medicine and Epidemiology, Columbia University, New York, NY ...
  • David T. Huang
    From the Heart Research Follow-up Program, University of Rochester Medical Center, NY (A.-C.R., A.J.M., V.K., M.H.R., D.T.H., H.K., S.M., C.A.B., M.W.B., W.Z.); Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (A.-C.R., M.H.R.); Division of Cardiology, Henry Ford Hospital, Detroit, MI (C.S.); Department of Medicine, University of Iowa Health Care, Iowa City (B.O.); St Luke’s and Roosevelt Hospitals, Departments of Medicine and Epidemiology, Columbia University, New York, NY ...
  • Helmut Klein
    From the Heart Research Follow-up Program, University of Rochester Medical Center, NY (A.-C.R., A.J.M., V.K., M.H.R., D.T.H., H.K., S.M., C.A.B., M.W.B., W.Z.); Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (A.-C.R., M.H.R.); Division of Cardiology, Henry Ford Hospital, Detroit, MI (C.S.); Department of Medicine, University of Iowa Health Care, Iowa City (B.O.); St Luke’s and Roosevelt Hospitals, Departments of Medicine and Epidemiology, Columbia University, New York, NY ...
  • Scott McNitt
    From the Heart Research Follow-up Program, University of Rochester Medical Center, NY (A.-C.R., A.J.M., V.K., M.H.R., D.T.H., H.K., S.M., C.A.B., M.W.B., W.Z.); Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (A.-C.R., M.H.R.); Division of Cardiology, Henry Ford Hospital, Detroit, MI (C.S.); Department of Medicine, University of Iowa Health Care, Iowa City (B.O.); St Luke’s and Roosevelt Hospitals, Departments of Medicine and Epidemiology, Columbia University, New York, NY ...
  • Christopher A. Beck
    From the Heart Research Follow-up Program, University of Rochester Medical Center, NY (A.-C.R., A.J.M., V.K., M.H.R., D.T.H., H.K., S.M., C.A.B., M.W.B., W.Z.); Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (A.-C.R., M.H.R.); Division of Cardiology, Henry Ford Hospital, Detroit, MI (C.S.); Department of Medicine, University of Iowa Health Care, Iowa City (B.O.); St Luke’s and Roosevelt Hospitals, Departments of Medicine and Epidemiology, Columbia University, New York, NY ...
  • Robert Goldstein
    From the Heart Research Follow-up Program, University of Rochester Medical Center, NY (A.-C.R., A.J.M., V.K., M.H.R., D.T.H., H.K., S.M., C.A.B., M.W.B., W.Z.); Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (A.-C.R., M.H.R.); Division of Cardiology, Henry Ford Hospital, Detroit, MI (C.S.); Department of Medicine, University of Iowa Health Care, Iowa City (B.O.); St Luke’s and Roosevelt Hospitals, Departments of Medicine and Epidemiology, Columbia University, New York, NY ...
  • Mary W. Brown
    From the Heart Research Follow-up Program, University of Rochester Medical Center, NY (A.-C.R., A.J.M., V.K., M.H.R., D.T.H., H.K., S.M., C.A.B., M.W.B., W.Z.); Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (A.-C.R., M.H.R.); Division of Cardiology, Henry Ford Hospital, Detroit, MI (C.S.); Department of Medicine, University of Iowa Health Care, Iowa City (B.O.); St Luke’s and Roosevelt Hospitals, Departments of Medicine and Epidemiology, Columbia University, New York, NY ...
  • Josef Kautzner
    From the Heart Research Follow-up Program, University of Rochester Medical Center, NY (A.-C.R., A.J.M., V.K., M.H.R., D.T.H., H.K., S.M., C.A.B., M.W.B., W.Z.); Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (A.-C.R., M.H.R.); Division of Cardiology, Henry Ford Hospital, Detroit, MI (C.S.); Department of Medicine, University of Iowa Health Care, Iowa City (B.O.); St Luke’s and Roosevelt Hospitals, Departments of Medicine and Epidemiology, Columbia University, New York, NY ...
  • Morio Shoda
    From the Heart Research Follow-up Program, University of Rochester Medical Center, NY (A.-C.R., A.J.M., V.K., M.H.R., D.T.H., H.K., S.M., C.A.B., M.W.B., W.Z.); Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (A.-C.R., M.H.R.); Division of Cardiology, Henry Ford Hospital, Detroit, MI (C.S.); Department of Medicine, University of Iowa Health Care, Iowa City (B.O.); St Luke’s and Roosevelt Hospitals, Departments of Medicine and Epidemiology, Columbia University, New York, NY ...
  • David Wilber
    From the Heart Research Follow-up Program, University of Rochester Medical Center, NY (A.-C.R., A.J.M., V.K., M.H.R., D.T.H., H.K., S.M., C.A.B., M.W.B., W.Z.); Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (A.-C.R., M.H.R.); Division of Cardiology, Henry Ford Hospital, Detroit, MI (C.S.); Department of Medicine, University of Iowa Health Care, Iowa City (B.O.); St Luke’s and Roosevelt Hospitals, Departments of Medicine and Epidemiology, Columbia University, New York, NY ...
  • Wojciech Zareba
    From the Heart Research Follow-up Program, University of Rochester Medical Center, NY (A.-C.R., A.J.M., V.K., M.H.R., D.T.H., H.K., S.M., C.A.B., M.W.B., W.Z.); Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (A.-C.R., M.H.R.); Division of Cardiology, Henry Ford Hospital, Detroit, MI (C.S.); Department of Medicine, University of Iowa Health Care, Iowa City (B.O.); St Luke’s and Roosevelt Hospitals, Departments of Medicine and Epidemiology, Columbia University, New York, NY ...
  • James P. Daubert
    From the Heart Research Follow-up Program, University of Rochester Medical Center, NY (A.-C.R., A.J.M., V.K., M.H.R., D.T.H., H.K., S.M., C.A.B., M.W.B., W.Z.); Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (A.-C.R., M.H.R.); Division of Cardiology, Henry Ford Hospital, Detroit, MI (C.S.); Department of Medicine, University of Iowa Health Care, Iowa City (B.O.); St Luke’s and Roosevelt Hospitals, Departments of Medicine and Epidemiology, Columbia University, New York, NY ...

説明

<jats:sec> <jats:title>Background—</jats:title> <jats:p>The benefit of novel implantable cardioverter defibrillator (ICD) programming in reducing inappropriate ICD therapy and mortality was demonstrated in Multicenter Automatic Defibrillator Implantation Trial-Reduce Inappropriate Therapy (MADIT-RIT). However, the cause of mortality reduction remains incompletely evaluated. We aimed to identify factors associated with mortality, with focus on ICD therapy and programming in the MADIT-RIT population.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods and Results—</jats:title> <jats:p> In MADIT-RIT, 1500 patients with a primary prophylactic indication for ICD or cardiac resynchronization therapy with defibrillator were randomized to 1 of 3 different ICD programming arms: conventional programming (ventricular tachycardia zone ≥170 beats per minute), high-rate programming (ventricular tachycardia zone ≥200 beats per minute), and delayed programming (60-second delay before therapy ≥170 beats per minute). Multivariate Cox models were used to assess the influence of time-dependent appropriate and inappropriate ICD therapy (shock and antitachycardia pacing) and randomized programming arm on all-cause mortality. During an average follow-up of 1.4±0.6 years, 71 of 1500 (5%) patients died: cardiac in 40 patients (56.3%), noncardiac in 23 patients (32.4%), and unknown in 8 patients (11.3%). Appropriate shocks (hazard ratio, 6.32; 95% confidence interval, 3.13–12.75; <jats:italic>P</jats:italic> <0.001) and inappropriate therapy (hazard ratio, 2.61; 95% confidence interval, 1.28–5.31; <jats:italic>P</jats:italic> =0.01) were significantly associated with an increased mortality risk. There was no evidence of increased mortality risk in patients who experienced appropriate antitachycardia pacing only (hazard ratio, 1.02; 95% confidence interval, 0.36–2.88; <jats:italic>P</jats:italic> =0.98). Randomization to conventional programming was identified as an independent predictor of death when compared with patients randomized to high-rate programming (hazard ratio, 2.0; 95% confidence interval, 1.06–3.71; <jats:italic>P</jats:italic> =0.03). </jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions—</jats:title> <jats:p>In MADIT-RIT, appropriate shocks, inappropriate ICD therapy, and randomization to conventional ICD programming were independently associated with an increased mortality risk. Appropriate antitachycardia pacing was not related to an adverse outcome.</jats:p> </jats:sec> <jats:sec> <jats:title>Clinical Trial Registration—</jats:title> <jats:p> URL: <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://clinicaltrials.gov">clinicaltrials.gov</jats:ext-link> Unique identifier: NCT00947310. </jats:p> </jats:sec>

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