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- Masahiro Aoki
- Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, BCC239, La Jolla, CA 92037; Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111; and Jefferson Medical College, 1020 Locust Street, Philadelphia, PA 19107
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- Osvaldo Batista
- Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, BCC239, La Jolla, CA 92037; Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111; and Jefferson Medical College, 1020 Locust Street, Philadelphia, PA 19107
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- Alfonso Bellacosa
- Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, BCC239, La Jolla, CA 92037; Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111; and Jefferson Medical College, 1020 Locust Street, Philadelphia, PA 19107
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- Philip Tsichlis
- Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, BCC239, La Jolla, CA 92037; Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111; and Jefferson Medical College, 1020 Locust Street, Philadelphia, PA 19107
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- Peter K. Vogt
- Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, BCC239, La Jolla, CA 92037; Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111; and Jefferson Medical College, 1020 Locust Street, Philadelphia, PA 19107
書誌事項
- 公開日
- 1998-12-08
- DOI
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- 10.1073/pnas.95.25.14950
- 公開者
- National Academy of Sciences
この論文をさがす
説明
<jats:p> The serine-threonine kinase Akt is a downstream target of phosphoinositide 3-kinase (PI 3-kinase); it is activated by the phosphoinositide 3-phosphate-dependent kinases PDK1 and PDK2. Certain mutated forms of Akt induce oncogenic transformation in chicken embryo fibroblast cultures and hemangiosarcomas in young chickens. This ability to transform cells depends on localization of Akt at the plasma membrane and on the kinase activity of Akt. A transdominant negative form of Akt interferes with oncogenic transformation induced by the <jats:italic>p3k</jats:italic> oncogene, which codes for an activated form of PI 3-kinase. Akt is therefore an essential mediator of <jats:italic>p3k</jats:italic> -induced oncogenicity. </jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 95 (25), 14950-14955, 1998-12-08
National Academy of Sciences
