Ph-like acute lymphoblastic leukemia: a high-risk subtype in adults

  • Nitin Jain
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX;
  • Kathryn G. Roberts
    Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN;
  • Elias Jabbour
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX;
  • Keyur Patel
    Department of Hematopathology,
  • Agda Karina Eterovic
    Institute for Personalized Cancer Therapy, and
  • Ken Chen
    Institute for Personalized Cancer Therapy, and
  • Patrick Zweidler-McKay
    Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX;
  • Xinyan Lu
    Department of Hematopathology,
  • Gloria Fawcett
    Institute for Personalized Cancer Therapy, and
  • Sa A. Wang
    Department of Hematopathology,
  • Sergej Konoplev
    Department of Hematopathology,
  • Richard C. Harvey
    Department of Pathology, University of New Mexico Comprehensive Cancer Center, Albuquerque, NM; and
  • I-Ming Chen
    Department of Pathology, University of New Mexico Comprehensive Cancer Center, Albuquerque, NM; and
  • Debbie Payne-Turner
    Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN;
  • Marcus Valentine
    Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN;
  • Deborah Thomas
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX;
  • Guillermo Garcia-Manero
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX;
  • Farhad Ravandi
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX;
  • Jorge Cortes
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX;
  • Steven Kornblau
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX;
  • Susan O’Brien
    Division of Hematology/Oncology, Chao Family Comprehensive Cancer Center, University of California Irvine Medical Center, Orange, CA
  • Sherry Pierce
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX;
  • Jeffrey Jorgensen
    Department of Hematopathology,
  • Kenna R. Mills Shaw
    Institute for Personalized Cancer Therapy, and
  • Cheryl L. Willman
    Department of Pathology, University of New Mexico Comprehensive Cancer Center, Albuquerque, NM; and
  • Charles G. Mullighan
    Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN;
  • Hagop Kantarjian
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX;
  • Marina Konopleva
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX;

説明

<jats:title>Key Points</jats:title> <jats:p>Approximately 20% to 25% of adults with B-ALL have Ph-like ALL with increased frequency of Ph-like ALL in adults with Hispanic ethnicity. Adult patients with CRLF2+ ALL have poor long-term outcomes; novel strategies are needed to improve the outcomes.</jats:p>

収録刊行物

  • Blood

    Blood 129 (5), 572-581, 2017-02-02

    American Society of Hematology

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