Endogenous PGE2 promotes the induction of human Th17 responses by fungal β-glucan

DOI PDF Web Site 被引用文献3件
  • Maria Cristina Gagliardi
    Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanità , Rome, Italy
  • Raffaela Teloni
    Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanità , Rome, Italy
  • Sabrina Mariotti
    Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanità , Rome, Italy
  • Carla Bromuro
    Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanità , Rome, Italy
  • Paola Chiani
    Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanità , Rome, Italy
  • Giulia Romagnoli
    Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanità , Rome, Italy
  • Federico Giannoni
    Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanità , Rome, Italy
  • Antonella Torosantucci
    Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanità , Rome, Italy
  • Roberto Nisini
    Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanità , Rome, Italy

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公開日
2010-08-31
権利情報
  • https://academic.oup.com/pages/standard-publication-reuse-rights
DOI
  • 10.1189/jlb.0310139
公開者
Oxford University Press (OUP)

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<jats:title>Abstract</jats:title> <jats:p>C. albicans β-glucan induces PGE2 production by human DC and promotes Th17 cell expansion.</jats:p> <jats:p>The interaction of PAMPs with cells of the innate immune system shapes the adaptive host response. Here, we report that β-glucan, a major fungal PAMP purified from Candida albicans, stimulates human DCs to secrete a pro-Th17 cytokine pattern. Notably, β-glucan induces PGE2 production, which has been shown to play a pivotal role in Th17 cell expansion. Inhibition of PGE2 synthesis or blockade of PGE2 receptors EP2 and EP4 drastically reduces IL-23 production by β-glucan-activated DCs, suggesting that endogenous PGE2 amplifies IL-23 synthesis in response to the C. albicans PAMP. Moreover β-glucan promotes the expansion of Th17 cells, which is strongly decreased by EP2 and EP4 receptor blockade on DCs. Our results highlight a novel role for PGE2 in the regulation of innate and adaptive immune response triggered by recognition of a prominent, highly conserved fungal PAMP such as β-glucan.</jats:p>

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