Recent progress in understanding molecular mechanisms of cartilage degeneration during osteoarthritis
書誌事項
- 公開日
- 2011-12
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1111/j.1749-6632.2011.06258.x
- 公開者
- Wiley
この論文をさがす
説明
<jats:p><jats:bold>Osteoarthritis (OA) is a highly prevalent disease affecting more than 20% of American adults. Predispositions include joint injury, heredity, obesity, and aging. Biomechanical alterations are commonly involved. However, the molecular mechanisms of this disease are complex, and there is currently no effective disease‐modifying treatment. The initiation and progression of OA subtypes is a complex process that at the molecular level probably involves many cell types, signaling pathways, and changes in extracellular matrix. <jats:italic>Ex vivo</jats:italic> studies with tissue derived from OA patients and <jats:italic>in vivo</jats:italic> studies with mutant mice have suggested that pathways involving receptor ligands such as TGF‐β1, WNT3a, and Indian hedgehog; signaling molecules such as Smads, β‐catenin, and HIF‐2a; and peptidases such as MMP13 and ADAMTS4/5 are probably involved to some degree. This review focuses on molecular mechanisms of OA development related to recent findings.</jats:bold></jats:p>
収録刊行物
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- Annals of the New York Academy of Sciences
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Annals of the New York Academy of Sciences 1240 (1), 61-69, 2011-12
Wiley
