Diverse developmental programs of <i>Xenopus laevis</i> metamorphosis are inhibited by a dominant negative thyroid hormone receptor
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- Alexander M. Schreiber
- Carnegie Institution of Washington, Department of Embryology, 115 West University Parkway, Baltimore, MD 21210
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- Biswajit Das
- Carnegie Institution of Washington, Department of Embryology, 115 West University Parkway, Baltimore, MD 21210
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- Haochu Huang
- Carnegie Institution of Washington, Department of Embryology, 115 West University Parkway, Baltimore, MD 21210
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- Nicholas Marsh-Armstrong
- Carnegie Institution of Washington, Department of Embryology, 115 West University Parkway, Baltimore, MD 21210
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- Donald D. Brown
- Carnegie Institution of Washington, Department of Embryology, 115 West University Parkway, Baltimore, MD 21210
書誌事項
- 公開日
- 2001-08-21
- DOI
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- 10.1073/pnas.191361698
- 公開者
- Proceedings of the National Academy of Sciences
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説明
<jats:p> Metamorphosis of anuran tadpoles is controlled by thyroid hormone (TH). Here we demonstrate that transgenic <jats:italic>Xenopus</jats:italic> <jats:italic>laevis</jats:italic> tadpoles expressing a dominant negative form of TH receptor-α are resistant to a wide variety of the metamorphic changes induced by TH. This result confirms that TH receptors mediate both early and late developmental programs of metamorphosis as diverse as growth in the brain, limb buds, nose and Meckel's cartilage, remodeling of the intestine, and death and resorption of the gills and tail. </jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 98 (19), 10739-10744, 2001-08-21
Proceedings of the National Academy of Sciences