The Gap Between the Physiological and Therapeutic Roles of Mesenchymal Stem Cells
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- Umberto Galderisi
- Sbarro Institute for Cancer Research and Molecular Medicine Center for Biotechnology Temple University Philadelphia Pennsylvania
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- Antonio Giordano
- Sbarro Institute for Cancer Research and Molecular Medicine College of Science and Technology Temple University BioLife Science Bldg., 1900 N, 12th Street Philadelphia Pennsylvania
説明
<jats:title>Abstract</jats:title><jats:p>Several investigators have cultivated marrow stromal cells and have identified a population of mesenchymal stem cells (MSCs). These cells expand extensively in vitro and exhibit multilineage differentiation potential. The lack of MSC‐specific markers impedes identification of MSC functions. Further in vivo studies of these cells may elucidate the nature of MSCs.</jats:p><jats:p>Although the nature of MSCs remains unclear, nonclonal stromal cultures are used as a source of putative MSCs for therapeutic purposes. Preclinical studies and clinical trials assumed that transplanted MSCs exert their effects through their differentiation properties or through the release of molecules that restore tissue functions and modulate immune cells. These studies reported contradictory results and failed to meet expectations. Thus, it is important to note that current protocols for MSC therapy are primarily based on the use of in vitro expanded nonclonal MSCs.</jats:p><jats:p>Clearly defining the physiological features of in situ MSCs and the in vitro and in vivo properties of nonclonal cultures of stromal cells, which are often misidentified as pure stem cell cultures, may explain the reported failures of MSC therapy. This review will address these issues.</jats:p>
収録刊行物
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- Medicinal Research Reviews
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Medicinal Research Reviews 34 (5), 1100-1126, 2014-05-28
Wiley
