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- Liming Bai
- Graduate School of Science and Technology and Department of Chemistry and Chemical Engineering, Niigata University, Ikarashi, 2-8050, Niigata 950-2181, Japan, Mitsubishi Gas Chemical Company Inc., Niigata Research Laboratory, 182, Shinwari, Tayuhama, Niigata 950-3112, Japan, Center for Biological Resources and Informatics, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan, KNC Laboratories Co., Ltd., 3-2-34 Takatsukadai, Nishi-ku, Kobe Hyogo 651-2271, Japan
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- Liyan Wang
- Graduate School of Science and Technology and Department of Chemistry and Chemical Engineering, Niigata University, Ikarashi, 2-8050, Niigata 950-2181, Japan, Mitsubishi Gas Chemical Company Inc., Niigata Research Laboratory, 182, Shinwari, Tayuhama, Niigata 950-3112, Japan, Center for Biological Resources and Informatics, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan, KNC Laboratories Co., Ltd., 3-2-34 Takatsukadai, Nishi-ku, Kobe Hyogo 651-2271, Japan
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- Ming Zhao
- Graduate School of Science and Technology and Department of Chemistry and Chemical Engineering, Niigata University, Ikarashi, 2-8050, Niigata 950-2181, Japan, Mitsubishi Gas Chemical Company Inc., Niigata Research Laboratory, 182, Shinwari, Tayuhama, Niigata 950-3112, Japan, Center for Biological Resources and Informatics, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan, KNC Laboratories Co., Ltd., 3-2-34 Takatsukadai, Nishi-ku, Kobe Hyogo 651-2271, Japan
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- Asami Toki
- Graduate School of Science and Technology and Department of Chemistry and Chemical Engineering, Niigata University, Ikarashi, 2-8050, Niigata 950-2181, Japan, Mitsubishi Gas Chemical Company Inc., Niigata Research Laboratory, 182, Shinwari, Tayuhama, Niigata 950-3112, Japan, Center for Biological Resources and Informatics, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan, KNC Laboratories Co., Ltd., 3-2-34 Takatsukadai, Nishi-ku, Kobe Hyogo 651-2271, Japan
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- Toshiaki Hasegawa
- Graduate School of Science and Technology and Department of Chemistry and Chemical Engineering, Niigata University, Ikarashi, 2-8050, Niigata 950-2181, Japan, Mitsubishi Gas Chemical Company Inc., Niigata Research Laboratory, 182, Shinwari, Tayuhama, Niigata 950-3112, Japan, Center for Biological Resources and Informatics, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan, KNC Laboratories Co., Ltd., 3-2-34 Takatsukadai, Nishi-ku, Kobe Hyogo 651-2271, Japan
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- Hirotsugu Ogura
- Graduate School of Science and Technology and Department of Chemistry and Chemical Engineering, Niigata University, Ikarashi, 2-8050, Niigata 950-2181, Japan, Mitsubishi Gas Chemical Company Inc., Niigata Research Laboratory, 182, Shinwari, Tayuhama, Niigata 950-3112, Japan, Center for Biological Resources and Informatics, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan, KNC Laboratories Co., Ltd., 3-2-34 Takatsukadai, Nishi-ku, Kobe Hyogo 651-2271, Japan
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- Takao Kataoka
- Graduate School of Science and Technology and Department of Chemistry and Chemical Engineering, Niigata University, Ikarashi, 2-8050, Niigata 950-2181, Japan, Mitsubishi Gas Chemical Company Inc., Niigata Research Laboratory, 182, Shinwari, Tayuhama, Niigata 950-3112, Japan, Center for Biological Resources and Informatics, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan, KNC Laboratories Co., Ltd., 3-2-34 Takatsukadai, Nishi-ku, Kobe Hyogo 651-2271, Japan
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- Katutoshi Hirose
- Graduate School of Science and Technology and Department of Chemistry and Chemical Engineering, Niigata University, Ikarashi, 2-8050, Niigata 950-2181, Japan, Mitsubishi Gas Chemical Company Inc., Niigata Research Laboratory, 182, Shinwari, Tayuhama, Niigata 950-3112, Japan, Center for Biological Resources and Informatics, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan, KNC Laboratories Co., Ltd., 3-2-34 Takatsukadai, Nishi-ku, Kobe Hyogo 651-2271, Japan
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- Junichi Sakai
- Graduate School of Science and Technology and Department of Chemistry and Chemical Engineering, Niigata University, Ikarashi, 2-8050, Niigata 950-2181, Japan, Mitsubishi Gas Chemical Company Inc., Niigata Research Laboratory, 182, Shinwari, Tayuhama, Niigata 950-3112, Japan, Center for Biological Resources and Informatics, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan, KNC Laboratories Co., Ltd., 3-2-34 Takatsukadai, Nishi-ku, Kobe Hyogo 651-2271, Japan
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- Jiao Bai
- Graduate School of Science and Technology and Department of Chemistry and Chemical Engineering, Niigata University, Ikarashi, 2-8050, Niigata 950-2181, Japan, Mitsubishi Gas Chemical Company Inc., Niigata Research Laboratory, 182, Shinwari, Tayuhama, Niigata 950-3112, Japan, Center for Biological Resources and Informatics, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan, KNC Laboratories Co., Ltd., 3-2-34 Takatsukadai, Nishi-ku, Kobe Hyogo 651-2271, Japan
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- Masayoshi Ando
- Graduate School of Science and Technology and Department of Chemistry and Chemical Engineering, Niigata University, Ikarashi, 2-8050, Niigata 950-2181, Japan, Mitsubishi Gas Chemical Company Inc., Niigata Research Laboratory, 182, Shinwari, Tayuhama, Niigata 950-3112, Japan, Center for Biological Resources and Informatics, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan, KNC Laboratories Co., Ltd., 3-2-34 Takatsukadai, Nishi-ku, Kobe Hyogo 651-2271, Japan
説明
Three new pregnanes, 21-hydroxypregna-4,6-diene-3,12,20-trione (1), 20R-hydroxypregna-4,6-diene-3,12-dione (2), and 16beta,17beta-epoxy-12beta-hydroxypregna-4,6-diene-3,20-dione (3), were isolated from Nerium oleander, together with two known compounds, 12beta-hydroxypregna-4,6,16-triene-3,20-dione (neridienone A, 4) and 20S,21-dihydroxypregna-4,6-diene-3,12-dione (neridienone B, 5). The structures of compounds 1-3 were established on the basis of their spectroscopic data. The anti-inflammatory activity in vitro of compounds 2-4 was examined on the basis of inhibitory activity against the induction of intercellular adhesion molecule-1 (ICAM-1), and compound 4 was active. The cytotoxic activity of compounds 1-5 was evaluated against four human cell lines, normal human fibroblast cells (WI-38), malignant tumor cells induced from WI-38 (VA-13), human liver tumor cells (HepG2), and human lung carcinoma cells (A-549). Compound 4 showed significant cell growth inhibition of VA-13 and HepG2 cells. The MDR-reversal activity of compounds 1-5 was evaluated on the basis of the amount of calcein accumulated in MDR human ovarian cancer 2780AD cells in the presence of each compound. Compounds 1, 2, and 5 showed significant effects on calcein accumulation.
収録刊行物
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- Journal of Natural Products
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Journal of Natural Products 70 (1), 14-18, 2006-12-23
American Chemical Society (ACS)
