Prevention of delayed vasospasm by an endothelin ETA receptor antagonist, BQ-123: change of ETA receptor mRNA expression in a canine subarachnoid hemorrhage model
説明
<jats:p content-type="fine-print">✓ The authors investigated the roles of endothelin (ET)-1 and the ET<jats:sub>A</jats:sub> receptor in the pathogenesis of delayed cerebral vasospasm following subarachnoid hemorrhage (SAH). A study was made of the preventive effect of a novel ET<jats:sub>A</jats:sub> receptor antagonist, BQ-123, on vasospasm and the expression of the ET<jats:sub>A</jats:sub> receptor messenger ribonucleic acid (mRNA) using a canine two-hemorrhage SAH model. Continuous intrathecal administration of BQ-123 (5 × 10<jats:sup>−6</jats:sup> mol/day) prevented narrowing of the basilar artery on Day 7 after SAH in 97.6% of cases in the study group versus 70.7% of cases in the control group (p < 0.05). While expression of the mRNA-coding ET<jats:sub>A</jats:sub> receptor was not detected in the control animals, it markedly increased on Day 3 after SAH and was also detected on Day 7. The results suggest that endothelin-1 and the ET<jats:sub>A</jats:sub> receptor participate in the pathogenesis of delayed cerebral vasospasm following SAH.</jats:p>
収録刊行物
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- Journal of Neurosurgery
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Journal of Neurosurgery 81 (5), 759-764, 1994-11
Journal of Neurosurgery Publishing Group (JNSPG)
