Activation of the Aryl Hydrocarbon Receptor by Structurally Diverse Exogenous and Endogenous Chemicals

DOI Web Site 被引用文献54件
  • Michael S. Denison
    Department of Environmental Toxicology, University of California, Davis, California 95616;
  • Scott R. Nagy
    Department of Environmental Toxicology, University of California, Davis, California 95616;

書誌事項

公開日
2003-04
DOI
  • 10.1146/annurev.pharmtox.43.100901.135828
公開者
Annual Reviews

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<jats:p> The induction of expression of genes for xenobiotic metabolizing enzymes in response to chemical insult is an adaptive response found in most organisms. In vertebrates, the AhR is one of several chemical/ligand-dependent intracellular receptors that can stimulate gene transcription in response to xenobiotics. The ability of the AhR to bind and be activated by a range of structurally divergent chemicals suggests that the AhR contains a rather promiscuous ligand binding site. In addition to synthetic and environmental chemicals, numerous naturally occurring dietary and endogenous AhR ligands have also been identified. In this review, we describe evidence for the structural promiscuity of AhR ligand binding and discuss the current state of knowledge with regards to the activation of the AhR signaling pathway by naturally occurring exogenous and endogenous ligands. </jats:p>

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