Non–invasive measurements of breast tissue optical properties using frequency–domain photon migration

DOI Web Site 被引用文献1件
  • Bruce J. Tromberg
    Beckman Laser Institute and Medical Clinic, University of California,Irvine, CA 92612–1475USA
  • Olivier Coquoz
    Beckman Laser Institute and Medical Clinic, University of California,Irvine, CA 92612–1475USA
  • Joshua B. Fishkin
    Beckman Laser Institute and Medical Clinic, University of California,Irvine, CA 92612–1475USA
  • Tuan Pham
    Beckman Laser Institute and Medical Clinic, University of California,Irvine, CA 92612–1475USA
  • Eric R. Anderson
    EA Photonics2515 Fisk Lane, Redondo Beach, CA 90278USA
  • John Butler
    Department of Surgery, Surgical Oncology, Clinical Cancer Center, UC Irvine Medical Center101 The City Drive, Orange, CA 92868USA
  • Mitchell Cahn
    Department of Surgery, Surgical Oncology, Clinical Cancer Center, UC Irvine Medical Center101 The City Drive, Orange, CA 92868USA
  • Jeffrey D. Gross
    Beckman Laser Institute and Medical Clinic, University of California,Irvine, CA 92612–1475USA
  • Vasan Venugopalan
    Beckman Laser Institute and Medical Clinic, University of California,Irvine, CA 92612–1475USA
  • David Pham
    Beckman Laser Institute and Medical Clinic, University of California,Irvine, CA 92612–1475USA
  • B. Chance
    editor
  • C. E. Cooper
    editor
  • D. T. Delpy
    editor
  • E. O. R. Reynolds
    editor

書誌事項

公開日
1997-06-29
権利情報
  • https://royalsociety.org/journals/ethics-policies/data-sharing-mining/
DOI
  • 10.1098/rstb.1997.0047
公開者
The Royal Society

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説明

<jats:p> A multiwavelength, high bandwidth (1 GHz) frequency–domain photon migration (FDPM) instrument has been developed for quantitative, non–invasive measurements of tissue optical and physiological properties. The instrument produces 300 kHz to 1 GHz photon density waves (PDWs) in optically turbid media using a network analyser, an avalanche photodiode detector and four amplitude–modulated diode lasers (674 nm, 811 nm, 849 nm and 956 nm). The frequency–dependence of PDW phase and amplitude is measured and compared to analytically derived model functions in order to calculate absorption, <jats:italic>μ</jats:italic> <jats:sub>a</jats:sub> , and reduced scattering, <jats:italic> μ <jats:sup>′</jats:sup> </jats:italic> <jats:sub>s</jats:sub> , parameters. The wavelength–dependence of absorption is used to determine tissue haemoglobin concentration (total, oxy– and deoxy– forms), oxygen saturation and water concentration. We present preliminary results of non–invasive FDPM measurements obtained from normal and tumour–containing human breast tissue. Our data clearly demonstrate that physiological changes caused by the presence of small (about 1 cm diameter) palpable lesions can be detected using a handheld FDPM probe. </jats:p>

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