Alkene 1,2‐Difunctionalization by Radical Alkenyl Migration

  • Xinjun Tang
    Westfälische Wilhelms-Universität Organisch-Chemisches Institut Corrensstraße 40 48149 Münster Germany
  • Armido Studer
    Westfälische Wilhelms-Universität Organisch-Chemisches Institut Corrensstraße 40 48149 Münster Germany

書誌事項

公開日
2017-12-14
権利情報
  • http://creativecommons.org/licenses/by-nc-nd/4.0/
DOI
  • 10.1002/anie.201710397
公開者
Wiley

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説明

<jats:title>Abstract</jats:title><jats:p>Transition‐metal‐free radical α‐perfluoroalkylation with the accompanying vicinal β‐alkenylation of unactivated alkenes is presented. These radical cascades proceed by means of 1,4‐ or 1,5‐alkenyl migration by electron catalysis on readily accessed allylic alcohols. The reactions comprise a regioselective perfluoroalkyl radical addition with subsequent alkenyl migration and concomitant deprotonation to generate a ketyl radical anion that sustains the chain as a single‐electron‐transfer reducing reagent.</jats:p>

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