Incomplete Stent Apposition After Implantation of Paclitaxel-Eluting Stents or Bare Metal Stents

  • Kengo Tanabe
    From the Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands (K.T., P.W.S., M.D., N.B., R.H., A.H., J.M.R.L.); Heart Center Siegburg, Siegburg, Germany (E.G.); Ospedali Riuniti di Bergamo, Bergamo, Italy (G.G.); Medizinische Klinik Weisser Hirsch, Dresden, Germany (W.U.); Catharina Ziekenhuis Eindhoven, Eindhoven, the Netherlands (J.B.); Hôpital Cardiologique–CHU, Lille, France (M.L.); J. Strus Hospital, Poznan, Poland (T.S.); Haukeland Hospital, Bergen, Norway (J.N.); Friedrich-Schiller...
  • Patrick W. Serruys
    From the Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands (K.T., P.W.S., M.D., N.B., R.H., A.H., J.M.R.L.); Heart Center Siegburg, Siegburg, Germany (E.G.); Ospedali Riuniti di Bergamo, Bergamo, Italy (G.G.); Medizinische Klinik Weisser Hirsch, Dresden, Germany (W.U.); Catharina Ziekenhuis Eindhoven, Eindhoven, the Netherlands (J.B.); Hôpital Cardiologique–CHU, Lille, France (M.L.); J. Strus Hospital, Poznan, Poland (T.S.); Haukeland Hospital, Bergen, Norway (J.N.); Friedrich-Schiller...
  • Muzaffer Degertekin
    From the Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands (K.T., P.W.S., M.D., N.B., R.H., A.H., J.M.R.L.); Heart Center Siegburg, Siegburg, Germany (E.G.); Ospedali Riuniti di Bergamo, Bergamo, Italy (G.G.); Medizinische Klinik Weisser Hirsch, Dresden, Germany (W.U.); Catharina Ziekenhuis Eindhoven, Eindhoven, the Netherlands (J.B.); Hôpital Cardiologique–CHU, Lille, France (M.L.); J. Strus Hospital, Poznan, Poland (T.S.); Haukeland Hospital, Bergen, Norway (J.N.); Friedrich-Schiller...
  • Eberhard Grube
    From the Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands (K.T., P.W.S., M.D., N.B., R.H., A.H., J.M.R.L.); Heart Center Siegburg, Siegburg, Germany (E.G.); Ospedali Riuniti di Bergamo, Bergamo, Italy (G.G.); Medizinische Klinik Weisser Hirsch, Dresden, Germany (W.U.); Catharina Ziekenhuis Eindhoven, Eindhoven, the Netherlands (J.B.); Hôpital Cardiologique–CHU, Lille, France (M.L.); J. Strus Hospital, Poznan, Poland (T.S.); Haukeland Hospital, Bergen, Norway (J.N.); Friedrich-Schiller...
  • Giulio Guagliumi
    From the Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands (K.T., P.W.S., M.D., N.B., R.H., A.H., J.M.R.L.); Heart Center Siegburg, Siegburg, Germany (E.G.); Ospedali Riuniti di Bergamo, Bergamo, Italy (G.G.); Medizinische Klinik Weisser Hirsch, Dresden, Germany (W.U.); Catharina Ziekenhuis Eindhoven, Eindhoven, the Netherlands (J.B.); Hôpital Cardiologique–CHU, Lille, France (M.L.); J. Strus Hospital, Poznan, Poland (T.S.); Haukeland Hospital, Bergen, Norway (J.N.); Friedrich-Schiller...
  • Wilhelm Urbaszek
    From the Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands (K.T., P.W.S., M.D., N.B., R.H., A.H., J.M.R.L.); Heart Center Siegburg, Siegburg, Germany (E.G.); Ospedali Riuniti di Bergamo, Bergamo, Italy (G.G.); Medizinische Klinik Weisser Hirsch, Dresden, Germany (W.U.); Catharina Ziekenhuis Eindhoven, Eindhoven, the Netherlands (J.B.); Hôpital Cardiologique–CHU, Lille, France (M.L.); J. Strus Hospital, Poznan, Poland (T.S.); Haukeland Hospital, Bergen, Norway (J.N.); Friedrich-Schiller...
  • Johannes Bonnier
    From the Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands (K.T., P.W.S., M.D., N.B., R.H., A.H., J.M.R.L.); Heart Center Siegburg, Siegburg, Germany (E.G.); Ospedali Riuniti di Bergamo, Bergamo, Italy (G.G.); Medizinische Klinik Weisser Hirsch, Dresden, Germany (W.U.); Catharina Ziekenhuis Eindhoven, Eindhoven, the Netherlands (J.B.); Hôpital Cardiologique–CHU, Lille, France (M.L.); J. Strus Hospital, Poznan, Poland (T.S.); Haukeland Hospital, Bergen, Norway (J.N.); Friedrich-Schiller...
  • Jean-Michel Lablanche
    From the Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands (K.T., P.W.S., M.D., N.B., R.H., A.H., J.M.R.L.); Heart Center Siegburg, Siegburg, Germany (E.G.); Ospedali Riuniti di Bergamo, Bergamo, Italy (G.G.); Medizinische Klinik Weisser Hirsch, Dresden, Germany (W.U.); Catharina Ziekenhuis Eindhoven, Eindhoven, the Netherlands (J.B.); Hôpital Cardiologique–CHU, Lille, France (M.L.); J. Strus Hospital, Poznan, Poland (T.S.); Haukeland Hospital, Bergen, Norway (J.N.); Friedrich-Schiller...
  • Tomasz Siminiak
    From the Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands (K.T., P.W.S., M.D., N.B., R.H., A.H., J.M.R.L.); Heart Center Siegburg, Siegburg, Germany (E.G.); Ospedali Riuniti di Bergamo, Bergamo, Italy (G.G.); Medizinische Klinik Weisser Hirsch, Dresden, Germany (W.U.); Catharina Ziekenhuis Eindhoven, Eindhoven, the Netherlands (J.B.); Hôpital Cardiologique–CHU, Lille, France (M.L.); J. Strus Hospital, Poznan, Poland (T.S.); Haukeland Hospital, Bergen, Norway (J.N.); Friedrich-Schiller...
  • Jan Nordrehaug
    From the Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands (K.T., P.W.S., M.D., N.B., R.H., A.H., J.M.R.L.); Heart Center Siegburg, Siegburg, Germany (E.G.); Ospedali Riuniti di Bergamo, Bergamo, Italy (G.G.); Medizinische Klinik Weisser Hirsch, Dresden, Germany (W.U.); Catharina Ziekenhuis Eindhoven, Eindhoven, the Netherlands (J.B.); Hôpital Cardiologique–CHU, Lille, France (M.L.); J. Strus Hospital, Poznan, Poland (T.S.); Haukeland Hospital, Bergen, Norway (J.N.); Friedrich-Schiller...
  • Hans Figulla
    From the Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands (K.T., P.W.S., M.D., N.B., R.H., A.H., J.M.R.L.); Heart Center Siegburg, Siegburg, Germany (E.G.); Ospedali Riuniti di Bergamo, Bergamo, Italy (G.G.); Medizinische Klinik Weisser Hirsch, Dresden, Germany (W.U.); Catharina Ziekenhuis Eindhoven, Eindhoven, the Netherlands (J.B.); Hôpital Cardiologique–CHU, Lille, France (M.L.); J. Strus Hospital, Poznan, Poland (T.S.); Haukeland Hospital, Bergen, Norway (J.N.); Friedrich-Schiller...
  • Janusz Drzewiecki
    From the Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands (K.T., P.W.S., M.D., N.B., R.H., A.H., J.M.R.L.); Heart Center Siegburg, Siegburg, Germany (E.G.); Ospedali Riuniti di Bergamo, Bergamo, Italy (G.G.); Medizinische Klinik Weisser Hirsch, Dresden, Germany (W.U.); Catharina Ziekenhuis Eindhoven, Eindhoven, the Netherlands (J.B.); Hôpital Cardiologique–CHU, Lille, France (M.L.); J. Strus Hospital, Poznan, Poland (T.S.); Haukeland Hospital, Bergen, Norway (J.N.); Friedrich-Schiller...
  • Adrian Banning
    From the Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands (K.T., P.W.S., M.D., N.B., R.H., A.H., J.M.R.L.); Heart Center Siegburg, Siegburg, Germany (E.G.); Ospedali Riuniti di Bergamo, Bergamo, Italy (G.G.); Medizinische Klinik Weisser Hirsch, Dresden, Germany (W.U.); Catharina Ziekenhuis Eindhoven, Eindhoven, the Netherlands (J.B.); Hôpital Cardiologique–CHU, Lille, France (M.L.); J. Strus Hospital, Poznan, Poland (T.S.); Haukeland Hospital, Bergen, Norway (J.N.); Friedrich-Schiller...
  • Karl Hauptmann
    From the Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands (K.T., P.W.S., M.D., N.B., R.H., A.H., J.M.R.L.); Heart Center Siegburg, Siegburg, Germany (E.G.); Ospedali Riuniti di Bergamo, Bergamo, Italy (G.G.); Medizinische Klinik Weisser Hirsch, Dresden, Germany (W.U.); Catharina Ziekenhuis Eindhoven, Eindhoven, the Netherlands (J.B.); Hôpital Cardiologique–CHU, Lille, France (M.L.); J. Strus Hospital, Poznan, Poland (T.S.); Haukeland Hospital, Bergen, Norway (J.N.); Friedrich-Schiller...
  • Dariusz Dudek
    From the Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands (K.T., P.W.S., M.D., N.B., R.H., A.H., J.M.R.L.); Heart Center Siegburg, Siegburg, Germany (E.G.); Ospedali Riuniti di Bergamo, Bergamo, Italy (G.G.); Medizinische Klinik Weisser Hirsch, Dresden, Germany (W.U.); Catharina Ziekenhuis Eindhoven, Eindhoven, the Netherlands (J.B.); Hôpital Cardiologique–CHU, Lille, France (M.L.); J. Strus Hospital, Poznan, Poland (T.S.); Haukeland Hospital, Bergen, Norway (J.N.); Friedrich-Schiller...
  • Nico Bruining
    From the Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands (K.T., P.W.S., M.D., N.B., R.H., A.H., J.M.R.L.); Heart Center Siegburg, Siegburg, Germany (E.G.); Ospedali Riuniti di Bergamo, Bergamo, Italy (G.G.); Medizinische Klinik Weisser Hirsch, Dresden, Germany (W.U.); Catharina Ziekenhuis Eindhoven, Eindhoven, the Netherlands (J.B.); Hôpital Cardiologique–CHU, Lille, France (M.L.); J. Strus Hospital, Poznan, Poland (T.S.); Haukeland Hospital, Bergen, Norway (J.N.); Friedrich-Schiller...
  • Ronald Hamers
    From the Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands (K.T., P.W.S., M.D., N.B., R.H., A.H., J.M.R.L.); Heart Center Siegburg, Siegburg, Germany (E.G.); Ospedali Riuniti di Bergamo, Bergamo, Italy (G.G.); Medizinische Klinik Weisser Hirsch, Dresden, Germany (W.U.); Catharina Ziekenhuis Eindhoven, Eindhoven, the Netherlands (J.B.); Hôpital Cardiologique–CHU, Lille, France (M.L.); J. Strus Hospital, Poznan, Poland (T.S.); Haukeland Hospital, Bergen, Norway (J.N.); Friedrich-Schiller...
  • Angela Hoye
    From the Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands (K.T., P.W.S., M.D., N.B., R.H., A.H., J.M.R.L.); Heart Center Siegburg, Siegburg, Germany (E.G.); Ospedali Riuniti di Bergamo, Bergamo, Italy (G.G.); Medizinische Klinik Weisser Hirsch, Dresden, Germany (W.U.); Catharina Ziekenhuis Eindhoven, Eindhoven, the Netherlands (J.B.); Hôpital Cardiologique–CHU, Lille, France (M.L.); J. Strus Hospital, Poznan, Poland (T.S.); Haukeland Hospital, Bergen, Norway (J.N.); Friedrich-Schiller...
  • Jurgen M.R. Ligthart
    From the Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands (K.T., P.W.S., M.D., N.B., R.H., A.H., J.M.R.L.); Heart Center Siegburg, Siegburg, Germany (E.G.); Ospedali Riuniti di Bergamo, Bergamo, Italy (G.G.); Medizinische Klinik Weisser Hirsch, Dresden, Germany (W.U.); Catharina Ziekenhuis Eindhoven, Eindhoven, the Netherlands (J.B.); Hôpital Cardiologique–CHU, Lille, France (M.L.); J. Strus Hospital, Poznan, Poland (T.S.); Haukeland Hospital, Bergen, Norway (J.N.); Friedrich-Schiller...
  • Clemens Disco
    From the Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands (K.T., P.W.S., M.D., N.B., R.H., A.H., J.M.R.L.); Heart Center Siegburg, Siegburg, Germany (E.G.); Ospedali Riuniti di Bergamo, Bergamo, Italy (G.G.); Medizinische Klinik Weisser Hirsch, Dresden, Germany (W.U.); Catharina Ziekenhuis Eindhoven, Eindhoven, the Netherlands (J.B.); Hôpital Cardiologique–CHU, Lille, France (M.L.); J. Strus Hospital, Poznan, Poland (T.S.); Haukeland Hospital, Bergen, Norway (J.N.); Friedrich-Schiller...
  • Jörg Koglin
    From the Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands (K.T., P.W.S., M.D., N.B., R.H., A.H., J.M.R.L.); Heart Center Siegburg, Siegburg, Germany (E.G.); Ospedali Riuniti di Bergamo, Bergamo, Italy (G.G.); Medizinische Klinik Weisser Hirsch, Dresden, Germany (W.U.); Catharina Ziekenhuis Eindhoven, Eindhoven, the Netherlands (J.B.); Hôpital Cardiologique–CHU, Lille, France (M.L.); J. Strus Hospital, Poznan, Poland (T.S.); Haukeland Hospital, Bergen, Norway (J.N.); Friedrich-Schiller...
  • Mary E. Russell
    From the Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands (K.T., P.W.S., M.D., N.B., R.H., A.H., J.M.R.L.); Heart Center Siegburg, Siegburg, Germany (E.G.); Ospedali Riuniti di Bergamo, Bergamo, Italy (G.G.); Medizinische Klinik Weisser Hirsch, Dresden, Germany (W.U.); Catharina Ziekenhuis Eindhoven, Eindhoven, the Netherlands (J.B.); Hôpital Cardiologique–CHU, Lille, France (M.L.); J. Strus Hospital, Poznan, Poland (T.S.); Haukeland Hospital, Bergen, Norway (J.N.); Friedrich-Schiller...
  • Antonio Colombo
    From the Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands (K.T., P.W.S., M.D., N.B., R.H., A.H., J.M.R.L.); Heart Center Siegburg, Siegburg, Germany (E.G.); Ospedali Riuniti di Bergamo, Bergamo, Italy (G.G.); Medizinische Klinik Weisser Hirsch, Dresden, Germany (W.U.); Catharina Ziekenhuis Eindhoven, Eindhoven, the Netherlands (J.B.); Hôpital Cardiologique–CHU, Lille, France (M.L.); J. Strus Hospital, Poznan, Poland (T.S.); Haukeland Hospital, Bergen, Norway (J.N.); Friedrich-Schiller...

書誌事項

タイトル別名
  • Insights From the Randomized TAXUS II Trial
公開日
2005-02-22
DOI
  • 10.1161/01.cir.0000155607.54922.16
公開者
Ovid Technologies (Wolters Kluwer Health)

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説明

<jats:p><jats:bold><jats:italic>Background—</jats:italic></jats:bold>The clinical impact of late incomplete stent apposition (ISA) for drug-eluting stents is unknown. We sought to prospectively investigate the incidence and extent of ISA after the procedure and at 6-month follow-up of paclitaxel-eluting stents in comparison with bare metal stents (BMS) and survey the clinical significance of ISA over a period of 12 months.</jats:p><jats:p><jats:bold><jats:italic>Methods and Results—</jats:italic></jats:bold>TAXUS II was a randomized, double-blind study with 536 patients in 2 consecutive cohorts comparing slow-release (SR; 131 patients) and moderate-release (MR; 135 patients) paclitaxel-eluting stents with BMS (270 patients). This intravascular ultrasound (IVUS) substudy included patients who underwent serial IVUS examination after the procedure and at 6 months (BMS, 240 patients; SR, 113; MR, 116). The qualitative and quantitative analyses of ISA were performed by an independent, blinded core laboratory. More than half of the instances of ISA observed after the procedure resolved at 6 months in all groups. No difference in the incidence of late-acquired ISA was observed among the 3 groups (BMS, 5.4%; SR, 8.0%; MR, 9.5%;<jats:italic>P</jats:italic>=0.306), with a similar ISA volume (BMS, 11.4 mm<jats:sup>3</jats:sup>; SR, 21.7 mm<jats:sup>3</jats:sup>; MR, 8.5 mm<jats:sup>3</jats:sup>;<jats:italic>P</jats:italic>=0.18). Late-acquired ISA was the result of an increase of vessel area without change in plaque behind the stent. Predictive factors of late-acquired ISA were lesion length, unstable angina, and absence of diabetes. No stent thrombosis occurred in the patients diagnosed with ISA over a period of 12 months.</jats:p><jats:p><jats:bold><jats:italic>Conclusions—</jats:italic></jats:bold>The incidence and extent of late-acquired ISA are comparable in paclitaxel-eluting stents and BMS. ISA is a pure IVUS finding without clinical repercussions.</jats:p>

収録刊行物

  • Circulation

    Circulation 111 (7), 900-905, 2005-02-22

    Ovid Technologies (Wolters Kluwer Health)

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