Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation
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- Simone Keck
- Laboratory of Transplantation Immunology, and
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- Mathias Schmaler
- Laboratory of Immunoregulation, Department of Biomedicine, University Hospital Basel, University of Basel, CH-4031 Basel, Switzerland;
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- Stefan Ganter
- Laboratory of Transplantation Immunology, and
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- Lena Wyss
- Laboratory of Transplantation Immunology, and
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- Susanne Oberle
- Swiss Vaccine Research Institute, and Division of Immunology and Allergy, Department of Medicine, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland; and
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- Eric S. Huseby
- Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655
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- Dietmar Zehn
- Swiss Vaccine Research Institute, and Division of Immunology and Allergy, Department of Medicine, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland; and
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- Carolyn G. King
- Laboratory of Transplantation Immunology, and
説明
<jats:title>Significance</jats:title><jats:p>T-cell receptor recognition of antigen is an essential first step in the initiation of a T-cell response. This report demonstrates that CD4 T cells responding during an infection can discriminate between antigen affinity and antigen dose, resulting in distinct types of effector and memory cell generation. Moreover, memory T cells “remember” the strength of primary T-cell activation and maintain a biased recall response upon secondary infection. These data reveal that antigen affinity exerts an important influence on T-cell differentiation that is not compensated for by high antigen dose. Understanding the rules of CD4 T-cell differentiation is integral to effective vaccine design.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 111 (41), 14852-14857, 2014-09-29
Proceedings of the National Academy of Sciences
