Glutathione Reductase: Stimulation in Normal Subjects by Riboflavin Supplementation

DOI Web Site 被引用文献1件
  • Ernest Beutler
    Division of Medicine, City of Hope Medical Center, Duarte, California

書誌事項

公開日
1969-08-08
DOI
  • 10.1126/science.165.3893.613
公開者
American Association for the Advancement of Science (AAAS)

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説明

<jats:p>Glutathione reductase of hemolyzates from clinically normal subjects is activated by the addition of flavin-adenine dinucleotide. One-half maximum stimulation could be achieved by approximately 0.02 micromolar flavin-adenine dinucleotide; prior addition of adenosine triphosphate, adenosine diphosphate, or adenosine monophosphate prevented activation. Stimulation of glutathione reductase activity of red cells of normal subjects occurred when they were given 5 milligrams of riboflavin daily for 8 days. The degree of stimulation in vitro by flavin-adenine dinucleotide and in vivo by riboflavin was inversely proportional to dietary intake of riboflavin. The variety of clinical disorders which have been associated with glutathione reductase deficiency may have, as a common denominator, abnormalities in flavin-adenine dinucleotide formation.</jats:p>

収録刊行物

  • Science

    Science 165 (3893), 613-615, 1969-08-08

    American Association for the Advancement of Science (AAAS)

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