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- Vineet D. Menachery
- Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;
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- Boyd L. Yount
- Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;
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- Amy C. Sims
- Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;
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- Kari Debbink
- Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;
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- Sudhakar S. Agnihothram
- Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079;
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- Lisa E. Gralinski
- Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;
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- Rachel L. Graham
- Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;
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- Trevor Scobey
- Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;
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- Jessica A. Plante
- Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;
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- Scott R. Royal
- Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;
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- Jesica Swanstrom
- Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;
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- Timothy P. Sheahan
- Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;
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- Raymond J. Pickles
- Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079;
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- Davide Corti
- Institute for Research in Biomedicine, Bellinzona, Switzerland;
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- Scott H. Randell
- Department of Cell Biology and Physiology and Marsico Lung Institute/Cystic Fibrosis Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;
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- Antonio Lanzavecchia
- Institute for Research in Biomedicine, Bellinzona, Switzerland;
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- Wayne A. Marasco
- Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute–Department of Medicine, Harvard Medical School, Boston MA 02215
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- Ralph S. Baric
- Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;
書誌事項
- 公開日
- 2016-03-14
- 権利情報
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- http://www.pnas.org/preview_site/misc/userlicense.xhtml
- DOI
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- 10.1073/pnas.1517719113
- 公開者
- Proceedings of the National Academy of Sciences
この論文をさがす
説明
<jats:title>Significance</jats:title> <jats:p>The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome (MERS)-CoV highlights the continued risk of cross-species transmission leading to epidemic disease. This manuscript describes efforts to extend surveillance beyond sequence analysis, constructing chimeric and full-length zoonotic coronaviruses to evaluate emergence potential. Focusing on SARS-like virus sequences isolated from Chinese horseshoe bats, the results indicate a significant threat posed by WIV1-CoV. Both full-length and chimeric WIV1-CoV readily replicated efficiently in human airway cultures and in vivo, suggesting capability of direct transmission to humans. In addition, while monoclonal antibody treatments prove effective, the SARS-based vaccine approach failed to confer protection. Together, the study indicates an ongoing threat posed by WIV1-related viruses and the need for continued study and surveillance.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 113 (11), 3048-3053, 2016-03-14
Proceedings of the National Academy of Sciences