Brain cell type–specific enhancer–promoter interactome maps and disease <b>-</b> risk association
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- Alexi Nott
- Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
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- Inge R. Holtman
- Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
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- Nicole G. Coufal
- Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
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- Johannes C. M. Schlachetzki
- Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
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- Miao Yu
- Ludwig Institute for Cancer Research, La Jolla, CA 92093, USA.
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- Rong Hu
- Ludwig Institute for Cancer Research, La Jolla, CA 92093, USA.
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- Claudia Z. Han
- Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
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- Monique Pena
- Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
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- Jiayang Xiao
- Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
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- Yin Wu
- Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
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- Zahara Keulen
- Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
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- Martina P. Pasillas
- Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
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- Carolyn O’Connor
- Flow Cytometry Core Facility, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
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- Christian K. Nickl
- Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
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- Simon T. Schafer
- Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
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- Zeyang Shen
- Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
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- Robert A. Rissman
- Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.
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- James B. Brewer
- Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.
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- David Gosselin
- Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
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- David D. Gonda
- Department of Neurosurgery, University of California, San Diego–Rady Children’s Hospital, San Diego, CA 92123, USA.
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- Michael L. Levy
- Department of Neurosurgery, University of California, San Diego–Rady Children’s Hospital, San Diego, CA 92123, USA.
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- Michael G. Rosenfeld
- Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
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- Graham McVicker
- The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
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- Fred H. Gage
- Section Molecular Neurobiology, Department of Biomedical Sciences of Cells & Systems, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, the Netherlands.
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- Bing Ren
- Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
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- Christopher K. Glass
- Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
説明
<jats:title>Linking enhancers to disease</jats:title> <jats:p> Enhancers are genomic regions that regulate gene expression, sometimes in a cell-dependent manner. However, most of our knowledge of human brain cell–type enhancers derives from studies of bulk human brain tissue. Nott <jats:italic>et al.</jats:italic> examined chromatin and promoter activity in cell nuclei isolated from human brains. Genetic variants associated with brain traits and disease showed cell-specific patterns of enhancer enrichment. These data indicate that Alzheimer's disease is regulated by genetic variants within microglial cells, whereas psychiatric diseases tend to affect neurons. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6469" page="1134" related-article-type="in-this-issue" vol="366" xlink:href="10.1126/science.aay0793">1134</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 366 (6469), 1134-1139, 2019-11-29
American Association for the Advancement of Science (AAAS)
