Psoriatic scales: a promising source for the isolation of human skin-derived antimicrobial proteins
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- Jürgen Harder
- Clinical Research Unit at the Department of Dermatology, University Hospital Schleswig-Holstein , Campus Kiel, Germany
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- Jens-Michael Schröder
- Clinical Research Unit at the Department of Dermatology, University Hospital Schleswig-Holstein , Campus Kiel, Germany
書誌事項
- 公開日
- 2005-01-03
- 権利情報
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- https://academic.oup.com/pages/standard-publication-reuse-rights
- DOI
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- 10.1189/jlb.0704409
- 公開者
- Oxford University Press (OUP)
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説明
<jats:title>Abstract</jats:title><jats:p>Patients with psoriasis, a chronic, hyperproliferative and noninfectious skin disease, suffer surprisingly fewer cutaneous infections than would be expected. This observation led us to the hypothesis that a local “chemical shield” in the form of antimicrobial proteins provides psoriatic skin with resistance against infection. We subsequently began a systematic analysis of in vitro antimicrobially active proteins in psoriatic-scale extracts. A biochemical approach with rigorous purification and characterization combined with antimicrobial testing identified a number of mostly new human antibiotic peptides and proteins. In this review, we will focus on the most prominent antimicrobial proteins in psoriatic-scale extracts, which we identified as the S100-protein psoriasin, human β-defensin 2 (hBD-2), RNase 7, lysozyme, and human neutrophil defensin 1–3. Apart from these cutaneous, antimicrobial proteins, only a few others, including hBD-3, have been characterized. A great number of minor antimicrobial proteins await further structural characterization.</jats:p>
収録刊行物
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- Journal of Leukocyte Biology
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Journal of Leukocyte Biology 77 (4), 476-486, 2005-01-03
Oxford University Press (OUP)